Whitaker Lecture : Biorheology in Thrombosis Research
Whitaker Lecture : Biorheology in Thrombosis Research
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通讯作者：
J.;D. Hellums
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作者：
J.;D. Hellums
-对血小板活化和血小板-血小板结合事件的生物流变学研究进行综述，这些事件在血栓形成和止血中发挥关键作用。许多工作人员已使用流变学方法来确定流体机械剪切应力作为 ptetetet 反应决定因素的重要性。流体机械剪切应力可以被视为始终存在于循环中并且与其他激动剂具有协同作用的血小板激动剂。早期的生物流变学研究是现象学的，因为它们关注应激对血小板功能测量的影响。随后的研究阐明了机制，并表明血小板活化的生化途径在高剪切应力下与许多血小板活化研究中使用的低剪切应力环境下有很大不同。血小板活化的生化途径在不同剪切应力水平下是不同的这一发现表明，有可能开发出具有高度特异性作用的血小板抑制剂：有可能抑制部分闭塞动脉中血栓形成的重要途径，而不严重损害血小板的正常止血功能。这项工作的另一个方面表明，生物流变学方法可能使得开发更好的方法来预测人类受试者的血栓形成倾向成为可能。关键词血小板、聚集、血液、止血、剪切应力。
-A review is presented on biorheological studies of platelet activation and platelet-platelet binding events that play key roles in thrombosis and hemostasis. Rheological methods have been used by a number of workers to establish the importance of fluid mechanical shear stress as a determinate of ptatetet reactions. Fluid mechanical shear stress can be regarded as a platelet agonist that is always present in the circulation and that is synergistic in its actions with other agonists. Early biorheological studies were phenomenological in that they focused on stress effects on measures of platelet function. Subsequent studies have elucidated mechanisms and have shown that the biochemical pathways of platelet activation are very different at elevated shear stresses than in the low shear stress environment used in many platelet activation studies. This finding that biochemical pathways of platelet activations are different at different shear stress levels suggests that it may be possible to develop platelet inhibitors of highly specific action: it may be possible to inhibit pathways important in thrombosis in a partially occluded artery without seriously compromising the normal hemostatic function of platelets. Another aspect of the work suggests that the biorheological approach may make it possible to develop better methods for prediction of thrombotic tendencies in human subjects. KeywordsmPlatelets, Aggregation, Blood, Hemostasis, Shear stress.