Regional axonal abnormalities in first episode schizophrenia:: Preliminary evidence based on high b-value diffusion-weighted imaging
Regional axonal abnormalities in first episode schizophrenia:: Preliminary evidence based on high b-value diffusion-weighted imaging
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DOI：
10.1016/j.pscychresns.2005.12.010
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发表时间：
2006-04-30
影响因子：
2.3
通讯作者：
Hendler, Talma
中科院分区：
文献类型：
--
作者：
Mendelsohn, Avi;Strous, Rael D.;Hendler, Talma
连接性被认为是精神分裂症患者大脑异常的主要来源。目前的研究集中在首发精神分裂症，以确定可能的早期病理轴突结构。首次发作的精神分裂症患者和健康对照者在1.5特斯拉扫描仪中进行扫描，在此期间获得高b值弥散加权成像（DWI）。直方图分析显示整体白色物质（WM）组织减少，表明精神分裂症组中的相对轴突异常。随后的分析发现，这种影响主要是由前额叶前束。此外，阳性和阴性症状严重程度与整个头部WM位移峰值之间存在负相关，这意味着整体上WM完整性程度较低与症状严重程度较高相关。这些初步结果表明，WM异常，如测量高b值DWI，已经是一个重要的病理性脑标志物在精神分裂症的早期阶段。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Connectivity has been implicated as a major source of brain abnormality in schizophrenia. The current study focused on first episode schizophrenia to identify possible early pathology in axonal structure. First episode schizophrenic patients and healthy controls were scanned in a 1.5-Tesla scanner during which high b-value diffusion-weighted imaging (DWI) was acquired. Histogram analysis revealed a decrease in overall white matter (WM) tissue, indicating relative axonal abnormality in the schizophrenic group. Subsequent analysis found that this effect was contributed mainly by anterior-prefrontal bundles. Moreover, negative correlations were found between positive and negative symptom severity and whole head WM displacement peak value, implying an overall lesser degree of WM integrity is associated with greater symptom severity. These preliminary results suggest that WM abnormality, as measured by high b-value DWI, is already a significant pathological brain marker in early stage of schizophrenia. (c) 2006 Elsevier Ireland Ltd. All rights reserved.