Cysteine string protein promotes proteasomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation.
Cysteine string protein promotes proteasomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation.
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半胱氨酸串蛋白通过增加其与 Hsp70 相互作用蛋白 C 末端的相互作用并促进 CFTR 泛素化,促进囊性纤维化跨膜电导调节因子 (CFTR) 的蛋白酶体降解。
DOI:
10.1074/jbc.m806485200
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发表时间:
2009
期刊:
影响因子:
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通讯作者:
Frizzell,RaymondA
中科院分区:
文献类型:
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作者:
Schmidt,BélaZ;Watts,RebeccaJ;Aridor,Meir;Frizzell,RaymondA