Work is related to a substantial portion of adult-onset asthma incidence in the Finnish population
Work is related to a substantial portion of adult-onset asthma incidence in the Finnish population
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DOI：
10.1164/ajrccm.164.4.2012146
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发表时间：
2001-08-15
影响因子：
24.7
通讯作者：
Karjalainen, J
中科院分区：
文献类型：
--
作者：
Karjalainen, A;Kurppa, K;Karjalainen, J
没有基于人群的随访研究来估计哮喘发病率中归因于工作的比例。在芬兰，患有临床确诊的持续性哮喘的个人登记后，可获得国家健康保险计划的药物报销。我们在个体水平上将这些数据与1985年、1990年和1995年的人口普查数据相结合，以估计成人发作持续性哮喘的归因工作比例。我们的后续研究涵盖了1986-1998年芬兰25- 59岁的就业人口。职业类别的相对风险（RR）估计相比，那些受雇于行政工作。有49，575例哮喘病例。男性的职业归因分数为29%（95% CI 25-33%），女性为17%（95% CI 15-19%）。特别是在农业工作、制造业工作和服务业工作中，风险增加。除了已经确定的职业性哮喘的风险职业，如食品和饮料工作，分析确定了大量的职业与哮喘发病率显着过剩。结果表明，职业因素在成人发作的持续性哮喘的发病过程中的影响，以及因此预防的潜力，比通常认为的要大得多，传播范围也更广。
There are no population-based follow-up studies to estimate the fraction of asthma incidence that is attributable to work. In Finland, individuals with clinically well-established persistent asthma are registered for reimbursement of medication from the national health insurance scheme. We combined, at an individual level, these data with the population census data of 1985, 1990, and 1995 to estimate the attributable fraction of work in adult-onset persistent asthma. Our follow-up study covered the entire 25- to 59-yr-old employed population of Finland in 1986-1998. Relative risks (RR) for occupational categories were estimated in comparison to those employed in administrative work. There were 49,575 incident cases of asthma. The attributable fraction of occupation was 29% (95% CI 25-33%) for men and 17% (95% CI 15-19%) for women. The risk was increased especially in agricultural work, manufacturing work, and service work. In addition to already established risk occupations of occupational asthma, such as food and beverage work, the analysis identified a large number of occupations with significant excess of asthma incidence. The results indicate that the impact of occupational factors in the inception of adult-onset persistent asthma, and consequently the potential for prevention, is much larger and more widely spread than generally assumed.