The reliability of measuring the density of the L1 vertebral body on CT imaging as a predictor of bone mineral density
The reliability of measuring the density of the L1 vertebral body on CT imaging as a predictor of bone mineral density
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DOI：
10.1016/j.crad.2016.09.022
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发表时间：
2017-02-01
影响因子：
2.6
通讯作者：
Bearcroft, P. W. P.
中科院分区：
文献类型：
--
作者：
Gerety, E. -L.;Hopper, M. A.;Bearcroft, P. W. P.
目的：确定在计算机断层扫描（CT）图像上测量的L1椎体密度是否与定量计算机断层扫描（QCT）测量的骨矿物质密度（BMD）相关，并确定不同观察者L1密度测量的可靠性，以了解该测量是否有助于识别从正式BMD评估中受益的患者。材料和方法：对30例健康人进行了沿着体模的非增强CT骨密度测定。结果：L1骨密度与QCT骨密度呈良好的相关性（相关系数0.83; 95%可信区间[CI]：0.67-0.92）。在L1密度测量中，观察者内和观察者间有很好的一致性。每个观察者在两个不同时间点的测量值具有极好的组内相关系数，观察者1的系数为0.94（95% CI：0.88-0.97），观察者2和3的系数为0.99（95% CI：0.98-1）。组内相关系数为0.98（95%CI：0.96-0.99）。结论：L1椎体骨密度可在CT图像上可靠测量，可作为骨质疏松症患者骨密度筛查的指标。CT成像上偶然检测到的低骨密度可用于识别应进一步检查和治疗骨质疏松症的患者。皇冠版权所有（C）2016由Elsevier Ltd代表皇家放射科医师学院发布。All rights reserved.
AIM: To determine whether the density of the L1 vertebra measured on computed tomography (CT) images correlates with the bone mineral density (BMD) as measured by quantitative computed tomography (QCT), and to determine the reliability of L1 density measurements by different observers to see if this measure could help identify patients who would benefit from formal BMD assessment.MATERIALS AND METHODS: Non-contrast CT along with a phantom for determination of BMD was performed on 30 healthy patients. The L1 density was measured by 3 observers at two time-points separated by at least 2 weeks.RESULTS: L1 density was well correlated to the QCT BMD (correlation coefficient 0.83; 95% confidence interval [CI]: 0.67-0.92). There was excellent intra-and interobserver agreement in L1 density measurements. There were excellent intra-class correlation coefficients for each observer's measurements at two separate time points with a coefficient for observer 1 of 0.94 (95% CI: 0.88-0.97) and for observer 2 and 3 of 0.99 (95% CI: 0.98-1). The interobserver measurements had an intra-class correlation coefficient of 0.98 (95% CI: 0.96-0.99).CONCLUSION: L1 vertebral density can be reliably measured on CT images and might be used as an indicator of BMD for opportunistic screening of patients with osteoporosis. Low bone density detected incidentally on CT imaging could be used to identify patients who should be further investigated and treated for osteoporosis. Crown Copyright (C) 2016 Published by Elsevier Ltd on behalf of The Royal College of Radiologists. All rights reserved.