Chemistry, structure, and function of insulin-like growth factors and their receptors: a review.
Chemistry, structure, and function of insulin-like growth factors and their receptors: a review.
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胰岛素样生长因子及其受体的化学、结构和功能：综述。
DOI：
10.1139/o84-158
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
J. Perdue
中科院分区：
文献类型：
--
作者：
J. Perdue
人血清中含有两类生长调节素 (Sm)，它们具有相似的三维结构和质量（即大约 7500 kdaltons (kd)），但可以通过其等电点 (pI) 值来区分。具有碱性 pI 的生长调节素包括可能相同的胰岛素样生长因子 I (IGF-I)、SmA、SmC 和碱性 Sm 分子。在人类中，Sm 代表中性酸性类别大鼠和其他动物的血清中含有相似类型的 Sm。在正常儿童和成人中，IGF-I 和 -II 的血浆水平均受生长激素控制，尽管只有前者浓度升高才与青少年骨骼生长呈正相关。然而，IGF-II 或其胚胎形式的血液水平升高与大鼠、绵羊甚至人类的胎儿发育相关。结合胰岛素和 IGF-I 的受体在免疫学、结构和功能上相关：胰岛素受体的单克隆和多克隆抗体识别结合 IGF-I 的受体上的决定簇；两种受体均具有 140、95 和可能 45 kd 的亚基，这些亚基通过链间二硫键连接形成相对质量 (Mr) 300 000 - 400 000 的糖蛋白复合物；激素或生长因子占据 140-kd 亚基会刺激受体相关蛋白激酶对 95-kd 亚基上的酪氨酸残基进行磷酸化。（摘要截断为 250 字）
Human serum contains two classes of somatomedins (Sm) with similar three-dimensional structures and mass (i.e., approximately 7500 kdaltons (kd), but that can be distinguished from each other by their isoelectric point (pI) values. Those with alkaline pI's include the presumably identical molecules of insulin-like growth factor I (IGF-I), SmA, SmC, and basic Sm. In humans, the neutral-acidic class of Sm is represented by IGF-II. The sera of rats and other animals contain similar classes of Sm. In normal children and adults, plasma levels of both IGF-I and -II are under growth hormone control, although only elevated concentrations of the former can be positively correlated with adolescent skeletal growth. Elevated blood levels of IGF-II or an embryonic form of it, however, are correlated with fetal development of rats, sheep, and possibly in humans. As evidenced from competitive radioreceptor binding studies and affinity-labelling techniques, receptors that bind insulin and IGF-I are immunologically, structurally, and functionally related: monoclonal and polyclonal antibodies to insulin receptors recognize determinants on receptors that bind IGF-I; both receptors have 140-, 95-, and possibly 45-kd subunits that are interchain disulfide-bonded to form glycoprotein complexes of relative masses (Mr) 300 000 - 400 000; and occupancy of the 140-kd subunits by hormone or growth factor stimulates the phosphorylation of tyrosine residues on the 95-kd subunit by receptor-associated protein kinases.(ABSTRACT TRUNCATED AT 250 WORDS)
生长调节素-C 和生长评估。
影响因子：
2.6
作者：
Underwood,LE;D'Ercole,AJ;VanWyk,JJ
通讯作者：
VanWyk,JJ