Contradictory Relationships between Cancer and Normal Cells and Implications for Anti-cancer Therapy.
Contradictory Relationships between Cancer and Normal Cells and Implications for Anti-cancer Therapy.
复制标题
DOI：
10.7314/apjcp.2015.16.13.5143
复制
发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Xing-chun Gou;D. Kong;Xu Tang
中科院分区：
文献类型：
--
作者：
Xing-chun Gou;D. Kong;Xu Tang
癌症治疗仍然是世界范围内的一个严重问题。分析癌细胞与正常细胞之间的关系，可以发现这两者具有矛盾的共同特征，因此可以用矛盾原理进行分析。在矛盾原理的理论下，诱导癌细胞进入休眠状态或逆转癌细胞是传统细胞毒性治疗之外的重要治疗策略。正常细胞也是抗癌治疗的目标和影响下，应该在治疗期间考虑。基于这两种细胞类型之间串扰的发现可能为开发新的生物标志物和疗法提供机会。
Cancer treatment remains a serious problem worldwide. Analysis of the relationship between cancer cells and normal cells reveals that these two share characteristics in contradiction, thus could be analyzed by using contradictory principles. Under the theory of contradictory principles, induction of a dormant state or reversal of cancer cells is an important treatment strategy beyond traditional cytotoxic therapy. Normal cells are also the targets and under the influence of anti-cancer treatments and should be considered during therapy. Findings based on crosstalk between these two cell types may offer opportunities for the development of new biomarkers and therapies.