Small hepatocellular carcinoma: Comparison of radio-frequency ablation and percutaneous microwave coagulation therapy
Small hepatocellular carcinoma: Comparison of radio-frequency ablation and percutaneous microwave coagulation therapy
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DOI：
10.1148/radiol.2232010775
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发表时间：
2002-05-01
期刊：
影响因子：
19.7
通讯作者：
Konishi, K
中科院分区：
文献类型：
--
作者：
Shibata, T;Iimuro, Y;Konishi, K
目的：评价射频消融联合经皮微波凝固治疗肝细胞癌的疗效。材料与方法：72例肝细胞癌患者94个结节，随机分为射频消融组和经皮微波凝固组。36例48个结节采用射频消融治疗，36例46个结节采用PMC治疗。结果：射频消融组每个结节的治疗次数明显低于PMC组(1.1次vs2.4次；P&t；.001)。射频消融48个结节中46个结节完全有效(96%)，PMC消融46个结节中完全有效41个(89%)(P=0.26)。主要并发症发生在1例接受射频消融的患者和4例接受PMC治疗的患者(P=.36)。随访6-27个月，射频消融治疗的48个结节中有4个结节残留病灶，PMC治疗的46个结节中有8个结节残留病灶。未经治疗的病灶残留率无显著差异(P=0.20，log-ranking检验)。结论：射频消融术和PMC目前为止具有相同的治疗效果、并发症发生率和未治疗的病灶残留率。然而，射频肿瘤消融可以用更少的次数实现。((C))RSNA，2002年。
PURPOSE: To evaluate the effectiveness of radio-frequency (RF) ablation and percutaneous microwave coagulation (PMC) for treatment of hepatocellular carcinoma (HCC).MATERIALS AND METHODS: Seventy-two patients with 94 HCC nodules were randomly assigned to RF ablation and PMC groups. Thirty-six patients with 48 nodules were treated with RF ablation, and 36 patients with 46 nodules were treated with PMC. Therapeutic effect, residual foci of untreated disease, and complications of RF ablation and PMC were prospectively evaluated with statistical analyses.RESULTS: The number of treatment sessions per nodule was significantly lower in the RF ablation group than in the PMC group (1.1 vs 2.4; P < .001). Complete therapeutic effect was achieved in 46 (96%) of 48 nodules treated with RF ablation and in 41 (89%) of 46 nodules treated with PMC (P = .26). Major complications occurred in one patient treated with RF ablation and in four patients treated with PMC (P = .36). During follow-up (range, 6-27 months), residual foci of untreated disease were seen in four of 48 nodules treated with RF ablation and in eight of 46 nodules treated with PMC. No significant difference in rates of residual foci of untreated disease was noted (P = .20, log-rank test).CONCLUSION: RF ablation and PMC thus far have had equivalent therapeutic effects, complication rates, and rates of residual foci of untreated disease. However, RF tumor ablation can be achieved with fewer sessions. ((C)) RSNA, 2002.