Treatment-related Lymphopenia in Patients With Stage III Non-Small-Cell Lung Cancer
Treatment-related Lymphopenia in Patients With Stage III Non-Small-Cell Lung Cancer
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DOI：
10.3109/07357907.2013.767342
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发表时间：
2013-03-01
影响因子：
2.4
通讯作者：
Grossman, Stuart A.
中科院分区：
文献类型：
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作者：
Campian, Jian L.;Ye, Xiaobu;Grossman, Stuart A.
背景：本研究旨在评估III期非小细胞肺癌患者治疗相关性淋巴细胞减少的严重程度、病因和临床重要性。方法：回顾性分析47例已知预后因素患者的系列淋巴细胞计数和生存率。结果：总淋巴细胞计数（TLCs）治疗前正常，新辅助化疗后无变化。放射后，薄层色谱下降67%（中位500个细胞/毫米）(3)
Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm(3), p