ForSim:: a tool for exploring the genetic architecture of complex traits with controlled truth
ForSim:: a tool for exploring the genetic architecture of complex traits with controlled truth
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DOI：
10.1093/bioinformatics/btn317
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发表时间：
2008-08-15
期刊：
影响因子：
5.8
通讯作者：
Weiss, Kenneth M.
中科院分区：
文献类型：
--
作者：
Lambert, Brian W.;Terwilliger, Joseph D.;Weiss, Kenneth M.
生物学中的许多重要问题都涉及到受基因组多个编码或调节部分影响的复杂特征。通过作图和关联研究等统计方法可以很好地推断潜在的遗传结构是活跃的研究领域。ForSim是一种灵活的正向进化模拟工具，用于根据表型探索进化的后果，由此人口统计、机会、行为和选择效应塑造遗传结构。模拟对于探索这些问题以及研究设计推理方法的选择都是有用的。
Many important problems in biology involve complex traits affected by multiple coding or regulatory parts of the genome. How well the underlying genetic architecture can be inferred by statistical methods such as mapping and association studies are active research areas. ForSim is a flexible forward evolutionary simulation tool for exploring the consequences of evolution by phenotype, whereby demographic, chance, behavioral and selective effects mold genetic architecture. Simulation is useful for exploring these issues as well as the choice of study design inferential methods.