Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI
Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI
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DOI：
10.1039/c2dt30388d
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发表时间：
2012-01-01
影响因子：
4
通讯作者：
Geraldes, C. F. G. C.
中科院分区：
文献类型：
--
作者：
Ferreira, M. F.;Mousavi, B.;Geraldes, C. F. G. C.
用Gd3+螯合物功能化的金纳米粒子具有快速的水交换、极好的pH稳定性和对锌离子转位的惰性，是一种新的高弛豫度(29 mm(-1)S(-1)，30 MHz，25℃)造影剂，可能是一种安全的体内MRI应用。采用Lipari-Szabo内旋转处理方法，考察了连接体柔性对金纳米颗粒弛豫度的影响。本文还讨论了快速水交换对Gd3+螯合物功能化的金纳米粒子弛豫性能的影响。
Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM(-1) s(-1), 30 MHz, 25 degrees C) contrast agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.