Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice
Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice
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DOI：
10.2131/jts.37.1279
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发表时间：
2012-12-01
影响因子：
2
通讯作者：
Naganuma, Akira
中科院分区：
文献类型：
--
作者：
Lee, Jin-Yong;Hwang, Gi-Wook;Naganuma, Akira
甲基汞处理的小鼠小脑中趋化因子基因Ccl2、Ccl4、Ccl7、Ccl9和Cell 2的表达增加。为了研究甲基汞对其他组织和器官的影响，研究了小鼠大脑、肾脏、肝脏和脾脏中趋化因子mRNA的水平。在大脑中，五种趋化因子的表达水平在甲基汞处理后显著增加。在肾脏中，Ccl2、Ccl7、Ccl9和Ccl12的表达水平增加，但Ccl4没有增加。对肝脏和脾脏中趋化因子的mRNA水平没有显著影响。因此，尽管甲基汞增加了大脑和肾脏中多种趋化因子的表达水平，但Ccl4的表达仅在大脑中增加。因此，这种现象可能与甲基汞对中枢神经系统的毒性有关。
Expression of the chemokine genes Ccl2, Ccl4, Ccl7, Ccl9, and Cell 2 is increased in cerebellum of mice treated with methylmercury. To investigate the effect of methylmercury on other tissues and organs, levels of chemokine mRNA were investigated in mouse cerebrum, kidney, liver, and spleen. In cerebrum, expression levels of the five chemokines were significantly increased after methylmercury treatment. In kidney, expression levels of Ccl2,Ccl7, Ccl9, and Ccl12, but not Ccl4 were increased. No significant effects were seen on mRNA levels of the chemokines in liver and spleen. Thus, although methylmercury increases the expression levels of multiple chemokines in the brain and kidney, expression of Ccl4 increases only in the brain. Hence, this phenomenon may be involved in methylmercury toxicity specific to the central nervous system.