Use of the total motile sperm count to predict total fertilization failure in in vitro fertilization
Use of the total motile sperm count to predict total fertilization failure in in vitro fertilization
复制标题
DOI：
10.1016/s0015-0282(02)03178-3
复制
发表时间：
2002-07-01
影响因子：
6.7
通讯作者：
van der Veen, F
中科院分区：
文献类型：
--
作者：
Repping, S;van Weert, JM;van der Veen, F
目的：评价体外受精患者基线特征和活动精子总数预测总受精失败的能力。设计：回顾性队列研究。地点：大学医院。患者(S)：892对夫妇，共1.569个连续的体外受精周期。干预(S)：在排卵过程中和取卵时洗涤前和洗后精子总数。主要结局衡量(S)：使用Logistic回归分析和受精者操作特征曲线确定哪些变量可用于预测总受精失败。结果(S)：生育检查期间预洗TMC的曲线下面积(AUC)为0.72，类似于洗前和洗后的TMC组合。在OPU成立之时。清洗前后TMC的AUC均为0.73。基于选定的基线特征(男性年龄。体外受精周期数、体外受精适应症和在生育检查期间预洗TMC)的AUC为0.75。一个模型在OPU的时候，包括卵母细胞的数量。AUC值为0.80。结论：两种模型均可使用。一次在试管受精周期开始前，一次在OPU时，可以准确地预测TFF的机会，并有助于咨询患者是否选择IVF或ICSI。(C)2002年，由美国生殖医学会提供。
Objective: To evaluate the capacity of baseline characteristics and total motile sperm count (TMC) to predict total fertilization failure (TIFF) in patients undergoing IVF.Design: Retrospective cohort study.Setting: University hospital.Patient(s): Eight hundred ninety-two couples with a total of 1.569 consecutive IVF cycles.Intervention(s): Prewash and postwash TMC during fertility workup and at the time of ovum pickup (OPU).Main Outcome Measure(s): Analysis of logistic regression and the receiver operating characteristic curve were used to determine which variables could be used to predict TIFF.Result(s): The area under the curve (AUC) for prewash TMC during fertility workup was 0.72, similar to a combination of pre- and postwash TMC. At the time of OPU. both pre- and postwash TMC had an AUC of 0.73. A model based on selected baseline characteristics (male age. number of IVF cycles, indication for IVF, and prewash TMC during fertility work-up) had an AUC of 0.75. A model at the time of OPU, including the number of oocytes. had an AUC of 0.80.Conclusion(s): The use of both models. one before start of the IVF cycle and one at the time of OPU, allows an accurate prediction of the chance of TFF and is useful in counseling patients on whether to opt for IVF or ICSI. (C) 2002 by American Society for Reproductive Medicine.