CEREBELLAR TOXICITY FOLLOWING HIGH-DOSE CYTOSINE-ARABINOSIDE
CEREBELLAR TOXICITY FOLLOWING HIGH-DOSE CYTOSINE-ARABINOSIDE
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DOI：
10.1200/jco.1985.3.5.613
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发表时间：
1985-01-01
影响因子：
45.3
通讯作者：
FUCHS, PC
中科院分区：
文献类型：
--
作者：
DWORKIN, LA;GOLDMAN, RD;FUCHS, PC
报告1例大剂量阿糖胞苷（3g/m2/12 h）治疗继发性急性非淋巴细胞白血病后发生急性小脑毒性的病例。共济失调和构音障碍的初始症状在30 g/m2累积剂量下出现，并在10周内持续无改善。大剂量阿糖胞苷进一步巩固治疗后小脑症状复发和恶化。随后的尸检显示小脑外侧半球广泛的浦肯野细胞损伤。在总剂量低于一般公认的剂量时，可能会发生持续的严重毒性。
A patient with acute cerebellar toxicity following systemic high-dose cytosine arabinoside (ara-C) 3 g/m2/12 h for secondary acute nonlymphocytic leukemia is reported. Initial symptoms of ataxia and dysarthria emerged at 30 g/m2 cumulative dose and persisted without improvement over a 10 wk period. Recurrence and worsening of cerebellar symptoms followed further consolidation treatment with high-dose ara-C. Subsequent autopsy showed extensive Purkinje''s cell damage in the lateral cerebellar hemispheres. Persistent severe toxicity can occur at total doses less than those generally recognized.