Fetal magnetocardiography (fMCG): moving forward in the establishment of clinical reference data by advanced biomagnetic instrumentation and analysis
Fetal magnetocardiography (fMCG): moving forward in the establishment of clinical reference data by advanced biomagnetic instrumentation and analysis
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DOI：
10.1515/jpm.2011.139
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发表时间：
2012-04-01
影响因子：
2.4
通讯作者：
Preissl, Hubert
中科院分区：
文献类型：
--
作者：
Kiefer-Schmidt, Isabelle;Lim, Minha;Preissl, Hubert
胎心宫缩描记法和超声心动图是目前胎心监测的标准方法。然而，两者都不能提供足够的时间分辨率来测量胎儿心脏时间间隔和检测正常窦性心律期间可能发生的心律失常。胎儿心磁图 (fMCG) 是一种测量胎儿心脏活动产生的磁信号的非侵入性技术。大多数 fMCG 设备安装在研究机构中，限制了该方法在临床环境中的实施。一些机构向前迈出了一步，在医院场所安装了设备，特别是用于胎儿检查的设备，以评估临床效益。基于可能影响信号质量的仪器差异，仍然没有建立胎儿心脏时间间隔的参考数据库。实施了专门用于胎儿记录的新型磁图仪，提高了患者的舒适度。优化设置以建立标准。总共记录了 103 个在妊娠前三个月后尽早开始的健康胎儿，并将心脏时间间隔的 fMCG 值与之前的研究进行了比较。从第 17 周开始，数据就可以对所有 fMCG 成分进行高度可靠的检测。这些数据与 fMCG 多中心研究、胎儿心电图和新生儿心电图结果相当，可以作为进一步研究胎儿心律失常的正常值数据库。
Cardiotocography and echocardiography are currently standard for fetal heart monitoring. However, both do not provide adequate temporal resolution to measure fetal cardiac time intervals and detect arrhythmias, which can occur during normal sinus rhythm. Fetal magnetocardiography (fMCG) is a non-invasive technique measuring magnetic signals generated by fetal heart activity. Most fMCG devices are installed in research institutions limiting the implementation of this method in a clinical setting. Several institutions made a step forward by installing devices, in particular for fetal investigations, in hospital sites to evaluate the clinical benefit. Based on instrumentation differences which can affect signal quality, there is still no established reference database for fetal cardiac time intervals. A new magnetograph dedicated to fetal recordings was implemented with improved patient comfort. The setting was optimized to establish a standard. A total of 103 healthy fetuses starting as early as possible after the first trimester were recorded and fMCG values of cardiac time intervals were compared to former studies. Data allowed high and reliable detection for all fMCG components starting at 17 weeks. The data were comparable to fMCG multicenter studies, fetal electrocardiography and neonatal ECG results and could serve as a database of norm values for further investigation of fetal arrhythmias.