Molecular imaging of in vivo gene expression.
Molecular imaging of in vivo gene expression.
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DOI：
10.4155/fmc.09.168
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发表时间：
2010-03
影响因子：
4.2
通讯作者：
Meade TJ
中科院分区：
文献类型：
--
作者：
Harney AS;Meade TJ
成像技术的进步在实验和转化研究中发挥了突出作用，并提供了基因表达变化如何与下游发育和疾病状态相关的重要信息。磁共振成像造影剂和光学探针用于增强特定酶、遗传标记、第二信使或代谢物存在时的信号强度，可以证明是一种促进对疾病进展中分子事件理解的简便方法。在疾病早期阶段检测基因表达变化的能力将导致对疾病进展的更好理解，使用早期治疗干预来增加患者的生存，并针对单个患者检测到的遗传改变定制治疗。
Advances in imaging technologies have taken a prominent role in experimental and translational research and provide essential information on how changes in gene expression are related to downstream developmental and disease states. Magnetic resonance imaging contrast agents and optical probes developed to enhance signal intensity in the presence of a specific enzyme, genetic marker, second messenger or metabolite can prove a facile method of advancing the understanding of molecular events in disease progression. The ability to detect changes in gene expression at the early stages of disease will lead to a greater understanding of disease progression, the use of early therapeutic intervention to increase patient survival, and tailored therapies to the detected genetic alterations in individual patients.