Ultrafast gelation of multifunctional hydrogel/composite based on self-catalytic Fe3+/Tannic acid-cellulose nanofibers
Ultrafast gelation of multifunctional hydrogel/composite based on self-catalytic Fe3+/Tannic acid-cellulose nanofibers
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DOI：
10.1016/j.jcis.2021.08.104
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发表时间：
2021-09-04
影响因子：
9.9
通讯作者：
Wei, Qufu
中科院分区：
文献类型：
--
作者：
Chen, Yajun;Wang, Di;Wei, Qufu
具有透明性、紫外线阻隔性、可拉伸性、自修复性、粘合性、抗氧化性和抗菌性的多功能水凝胶是生物医学和相关应用的有前途的材料。然而，在没有刺激的环境中制备这些水凝胶仍然是一个挑战。本文以自催化Fe ~（3+）/单宁酸-纤维素三元共聚物（Fe ~（3+）/TA-CNF）为基础，制备了一系列室温或低温下具有超短凝胶时间（约30 s）的水凝胶。Fe 3 +/TA-CNF形成稳定的氧化还原对，活化引发剂过硫酸铵，产生大量自由基引发丙烯酸（AA）超快聚合。为提高水凝胶的抗菌性能，采用温和浇铸法制备了载四环素（TH）的电纺纳米纤维与水凝胶层构成的双层水凝胶复合材料（NF@HG）。NF@HG具有增强的抗菌能力，TH的持续释放可以提供长期的抗菌活性。此外，细胞活力结果表明NF@HG无细胞毒性。总之，这种基于自催化Fe 3 +/TA-CNF体系的策略可能会激发快速经济地制备多功能水凝胶或复合材料的新方面，这些多功能水凝胶或复合材料在生物医学材料中具有有吸引力的工业应用。(C)2021爱思唯尔公司All rights reserved.
Multifunctional hydrogels with transparency, ultraviolet (UV)-blocking, stretchable, self-healing, adhesive, antioxidant and antibacterial properties are promising materials for biomedical and relevant applications. However, preparation of these hydrogels at ambient environment without stimuli is still a challenge. Here, a series of hydrogels possessing ultrashort gelation time (similar to 30 s) at room or cold temperature were fabricated based on self-catalytic Fe3+/Tannic acid-cellulose nanofiber (Fe3+/TA-CNF). Fe3+/TA-CNF formed stable redox pairs to activate ammonium persulfate (initiator), generating abundant free radicals to trigger the ultrafast polymerization of acrylic acid (AA). To improve the antibacterial ability of hydrogel, a bilayer hydrogel composite (NF@HG) composed of tetracycline hydrochloride (TH)-loaded electrospun nanofibers and hydrogel layer was fabricated via a mild casting method. The NF@HG exhibited enhanced antibacterial ability and the sustained release of TH can provide long-term antibacterial activity. Besides, cell viability results demonstrated that NF@HG was non-cytotoxic. Taken together, this strategy based on self-catalytic Fe3+/TA-CNF system may inspire new aspects on fast and economical preparation of multifunctional hydrogels or composites, which have attractive industrial applications for biomedical materials. (C) 2021 Elsevier Inc. All rights reserved.