Antimicrobial resistance in healthcare, agriculture and the environment: the biochemistry behind the headlines.
Antimicrobial resistance in healthcare, agriculture and the environment: the biochemistry behind the headlines.
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DOI：
10.1042/ebc20160053
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发表时间：
2017-02-28
影响因子：
6.4
通讯作者：
Begg SL
中科院分区：
文献类型：
--
作者：
Venter H;Henningsen ML;Begg SL
抗菌素耐药性(AMR)危机是当今面临的最严重的问题之一。各国国家元首最近在联合国承诺协调努力遏制AMR感染的传播，这说明了问题的严重性。在这篇综述中，我们探索了最近在公共媒体上发表的几个故事标题背后的生物化学。我们侧重于与AMR有关的三个不同问题的例子：(I)医院获得性感染，(Ii)耐药性通过动物和/或环境的传播，以及(Iii)抗菌肥皂和其他含有消毒剂的产品在AMR传播中的作用。尽管这些故事来自三个非常不同的背景，但所有故事背后的信息都是相同的：抗菌剂的使用与耐药性的发展之间存在直接关系。此外，一种类型的抗菌剂可以选择对另一种类型的交叉耐药性和/或多药耐药性。因此，我们主张加强监管，不仅包括抗生素的临床使用，还包括在农业中使用抗菌剂，以及对我们至关重要的杀生剂，如洗必泰的监管。
The crisis of antimicrobial resistance (AMR) is one of the most serious issues facing us today. The scale of the problem is illustrated by the recent commitment of Heads of State at the UN to coordinate efforts to curb the spread of AMR infections. In this review, we explore the biochemistry behind the headlines of a few stories that were recently published in the public media. We focus on examples from three different issues related to AMR: (i) hospital-acquired infections, (ii) the spread of resistance through animals and/or the environment and (iii) the role of antimicrobial soaps and other products containing disinfectants in the dissemination of AMR. Although these stories stem from three very different settings, the underlying message in all of them is the same: there is a direct relationship between the use of antimicrobials and the development of resistance. In addition, one type of antimicrobial could select for cross-resistance to another type and/or for multidrug resistance. Therefore, we argue the case for increased stewardship to not only cover clinical use of antibiotics, but also the use of antimicrobials in agriculture and stewardship of our crucially important biocides such as chlorhexidine.