The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food.
The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food.
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DOI：
10.1097/fbp.0b013e32834f9f9d
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发表时间：
2012-04
影响因子：
1.6
通讯作者：
Lamb RJ
中科院分区：
文献类型：
--
作者：
Ginsburg BC;Pinkston JW;Lamb RJ
当每种选择性血清素再摄取抑制剂氟伏沙明以单独的成分或单独的大鼠组提供时，以低于食物的剂量可减少对乙醇的反应。然而，当两者同时可用且每次疗程获得的分娩量相等时，这种明显的选择性反转，并且食物维持的行为比乙醇维持的行为对氟伏沙明的速率降低作用更敏感。在这里，我们进一步研究同时获取食物和乙醇对氟伏沙明效力的影响。在同时提供食物和乙醇且反应率相等（食物和乙醇的平均可变间隔（VI）分别为 405-s 和 14-s）以及当食物输送密度增加（平均 VI 60-s 食物和 VI 14-s 乙醇）的条件下评估氟伏沙明（5.6-17.8 mg/kg）效力。氟伏沙明的效力也被确定在只有乙醇可用时（食物灭绝和平均 VI 14-s 乙醇）和多重 VI（VI 30-s 食物和乙醇）下，其中食物或乙醇是每个组件中唯一可用的程序强化剂。当同时提供食物时（ED50 [95% C.L.]：8.2 [6.5-10.3]和10.7 [7.9-14.4]）与单独提供乙醇时（ED50：4.0 [2.7-5.9]和5.1 [4.3-6.0]）相比，氟伏沙明在减少乙醇自我给药方面的效力较差。在可获得食物的每种条件下，对食物的影响相似。结果表明，氟伏沙明减少乙醇维持行为的效力取决于乙醇是否可以单独使用或在同时安排的食物强化的情况下使用。
The selective serotonin reuptake inhibitor fluvoxamine reduces responding for ethanol at lower doses than responding for food when each is available in separate components or separate groups of rats. However, when both are available concurrently and deliveries earned per session are equal, this apparent selectivity inverts and food-maintained behavior is more sensitive than ethanol-maintained behavior to rate-decreasing effects of fluvoxamine. Here, we investigate further the impact concurrent access to both food and ethanol has on the potency of fluvoxamine. Fluvoxamine (5.6-17.8 mg/kg) potency was assessed under conditions where food and ethanol were available concurrently and response rates were equal (average variable intervals (VI) 405-s and 14-s for food and ethanol, respectively), as well as when density of food delivery was increased (average VI 60-s food & VI 14-s ethanol). The potency of fluvoxamine was also determined when only ethanol was available (food extinction and average VI 14-s ethanol) and under a multiple VI (VI 30-s food and ethanol) where either food or ethanol was the only programmed reinforcer available during each component. Fluvoxamine was less potent at decreasing ethanol self-administration when food was available concurrently (ED50 [95% C.L.]: 8.2 [6.5-10.3] & 10.7 [7.9-14.4]) versus when ethanol was available in isolation (ED50: 4.0 [2.7-5.9] & 5.1 [4.3-6.0]). Effects on food were similar under each condition where food was available. The results demonstrate that the potency of fluvoxamine to reduce ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement.