Chemotaxis and Phagocytosis in Neutrophils Is Independent of Coronin 11
Chemotaxis and Phagocytosis in Neutrophils Is Independent of Coronin 11
复制标题
中性粒细胞的趋化性和吞噬作用不依赖于 Coronin 11
作者：
B. Combaluzier;J. Pieters
WD 重复蛋白家族成员 Coronin 1 仅在白细胞中表达，与皮质细胞骨架共定位。尽管最初认为 Coronin 1 可以调节 F-肌动蛋白动力学，例如白细胞运动、吞噬作用和膜皱褶，但最近的研究表明，在巨噬细胞、T 细胞和 B 细胞中，Coronin 1 对于这些 F-肌动蛋白依赖性过程是可有可无的，而是参与钙依赖性信号传导反应的调节。在这项研究中，我们表明，在缺乏 Coronin 1 的小鼠中，中性粒细胞群体发育正常，并且缺乏 Coronin 1 的中性粒细胞在粘附、膜动力学、迁移、吞噬作用和氧化爆发方面功能齐全。因此，这些数据反对 Coronin 1 在 F-肌动蛋白调节中的作用，并表明 Coronin 1 对于中性粒细胞功能来说是可有可无的。
The WD repeat protein family member coronin 1 is exclusively expressed in leukocytes, where it colocalizes with the cortical cytoskeleton. Although initially coronin 1 was believed to regulate F-actin dynamics such as leukocyte motility, phagocytosis, and membrane ruffling, recent work showed that in macrophages, T cells, and B cells, coronin 1 is dispensable for these F-actin dependent processes, instead being involved in the regulation of calcium dependent signaling reactions. In this study, we show that in mice lacking coronin 1 neutrophil populations developed normally, and that coronin 1-deficient neutrophils are fully functional with respect to adherence, membrane dynamics, migration, phagocytosis and the oxidative burst. Therefore, these data argue against a role for coronin 1 in the modulation of F-actin and suggest that coronin 1 is dispensable for neutrophil functioning.
影响因子：
32.4
作者：
Stark, MA;Huo, YQ;Ley, K
通讯作者：
Ley, K