GENETIC CHARACTERISTICS OF HELA-CELL
GENETIC CHARACTERISTICS OF HELA-CELL
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DOI：
10.1126/science.1246620
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
BODMER, WF
中科院分区：
文献类型：
--
作者：
HSU, SH;SCHACTER, BZ;BODMER, WF
从她丈夫和孩子的表型以及对HeLa细胞的研究中推断出亨丽埃塔缺乏的宫颈癌患者的基因型别。在HeLa中葡萄糖-6-磷酸脱氢酶的半合子表达，以及推测的拉克斯夫人的杂合性，与她的肿瘤的克隆起源是一致的。
The genotype of the patient Henrietta Lacks from whose cervical carcinoma the HeLa cell was derived was deduced from the phenotypes of her husband and children, and from studies of the HeLa cell. Hemizygous expression of glucose-6-phosphate dehydrogenase in HeLa, together with the deduced heterozygosity of Mrs. Lacks, is consistent with clonal origin of her neoplasm.