Brain-Spleen Inflammatory Coupling: A Literature Review.
Brain-Spleen Inflammatory Coupling: A Literature Review.
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DOI：
10.23861/ejbm20112768
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Casper D
中科院分区：
文献类型：
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作者：
Rasouli J;Lekhraj R;Ozbalik M;Lalezari P;Casper D
最近的证据表明，脑损伤与脾巨噬细胞自主释放促炎细胞因子之间存在联系。这种现象被称为“脑脾炎症耦合”，已经引起了科学界和医学界对开发创伤性脑损伤（TBI）新疗法的关注。脾巨噬细胞α7亚基烟碱乙酰胆碱受体（α7NAchR）的胆碱能刺激已被证明可抑制其释放促炎细胞因子。这种由副交感神经系统介导的抑制作用已被证明可以改善败血症、中风和TBI动物模型的预后。随着脾抑制有益作用的证据越来越多，新的治疗策略可能适用于许多涉及神经炎症的医疗条件，这一过程有助于进一步的神经退化。
Recent evidence suggests a link between brain injury and the autonomic release of pro-inflammatory cytokines by resident macrophages in the spleen. This phenomenon, termed “brain-spleen inflammatory coupling,” has garnered attention from scientific and medical communities interested in developing novel treatments for traumatic brain injury (TBI). Cholinergic stimulation of the α7-subunit nicotinic acetylcholine receptor (α7NAchR) on splenic macrophages has been shown to inhibit their release of pro-inflammatory cytokines. This inhibition, mediated by the parasympathetic nervous system, has been shown to improve outcomes in animal models of sepsis, stroke, and TBI. As evidence of a beneficial role of splenic inhibition grows, new treatment strategies might be applied to many medical conditions involving neuroinflammation, a process that contributes to further neurological deterioration.