A randomized controlled trial on the psychophysiological effects of physical exercise and Tai-chi in patients with chronic schizophrenia
A randomized controlled trial on the psychophysiological effects of physical exercise and Tai-chi in patients with chronic schizophrenia
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DOI：
10.1016/j.schres.2016.01.038
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发表时间：
2016-03-01
影响因子：
4.5
通讯作者：
Chen, Eric Y. H.
中科院分区：
文献类型：
--
作者：
Ho, Rainbow T. H.;Fong, Ted C. T.;Chen, Eric Y. H.
精神分裂症的慢性和流行性导致患者长期住院。传统的抗精神病药物治疗精神病症状往往会带来严重的副作用，降低患者的幸福感。太极拳是一种强调运动协调和放松的身心运动。这项3臂随机对照试验研究了太极拳对153名慢性精神分裂症患者的心理生理学益处，这些患者从心理健康康复中心招募，并随机分为太极拳，运动或候补对照组。两个干预组都接受了12周的特定干预加上对照组接受的标准药物治疗。所有参与者在基线、3个月和6个月随访时完成精神病访谈、自我报告问卷、绩效任务和唾液皮质醇测量，以评估精神病症状、运动协调、记忆、日常生活功能和压力。采用多组潜在生长模型评价干预对结局的影响。与对照组相比，太极组表现出显着减少运动缺陷和增加向后数字跨度和平均皮质醇，而运动组表现出显着减少运动缺陷，消极和抑郁症状和增加向前数字跨度，日常生活功能，平均皮质醇。两种干预措施没有显示出显着不同的治疗效果，除了运动组的症状表现较少。这些结果表明太极拳对慢性精神分裂症患者在运动协调和记忆方面的心理生理益处。虽然太极和运动组都倾向于表现出比对照组更少的症状，但运动组表现出比太极组更好的症状管理。(C)2016爱思唯尔B.V.保留所有权利。
The chronic and prevalent natures of schizophrenia result in long-term institutionalization for the patients. Conventional treatment of anti-psychotic medication on management of psychotic symptoms often brings on severe side effects and reduces patients' well-being. Tai-chi is a mind-body exercise that underscores motor coordination and relaxation. This 3-arm randomized controlled trial investigated the psychophysiological benefits of Tai-chi on 153 chronic schizophrenia patients, who were recruited from a mental health rehab complex and randomized into Tai-chi, exercise, or waitlist control groups. Both intervention groups received 12 weeks of specific intervention plus standard medication received by the controls. All participants completed psychiatric interviews, self-report questionnaires, performance tasks, and salivary cortisol measures at baseline, 3-month, and 6-month follow-up on psychotic symptoms, motor coordination, memory, daily living function, and stress. Multi-group latent growth modeling was used to evaluate the intervention effects on the outcomes. Compared to controls, the Tai-chi group showed significant decreases in motor deficits and increases in backward digit span and mean cortisol, while the exercise group displayed significant decreases in motor deficits, negative and depression symptoms and increases in forward digit span, daily living function, and mean cortisol. The two interventions did not show significantly different therapeutic effects, except for fewer symptom manifestations in the exercise group. These results suggest psychophysiological benefits for Tai-chi on chronic schizophrenia patients in terms of motor coordination and memory. Though both Tai-chi and exercise groups tended to manifest fewer symptoms than the control group, the exercise group showed better symptoms management than the Tai-chi group. (C) 2016 Elsevier B.V. All rights reserved.