Reproductive outcomes in the women of the Red River Valley of the north. I. The spouses of pesticide applicators: pregnancy loss, age at menarche, and exposures to pesticides
Reproductive outcomes in the women of the Red River Valley of the north. I. The spouses of pesticide applicators: pregnancy loss, age at menarche, and exposures to pesticides
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DOI：
10.1080/00984100290071333
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发表时间：
2002-06-14
影响因子：
2.6
通讯作者：
Long, L
中科院分区：
文献类型：
--
作者：
Garry, VF;Harkins, M;Long, L
在目前的研究中，在使用杀菌剂的施用者的配偶中，全年发生流产和/或胎儿丢失的风险适度但显著增加（1.6至2倍）。杀真菌剂施用者配偶所生男孩数量惊人地显著不足。妊娠早期流产最常发生在春季，在除草剂施用期间，男性施用者使用磺酰脲类（比值比OR = 2.1）、含咪唑啉酮（OR = 2.6）的除草剂和除草剂组合夏延（OR = 2.9）与春季流产风险增加有统计学相关性。来自施用者配偶的妇女的有限调查数据未显示长期内分泌状态（初潮、绝经、子宫内膜异位症）的重大改变。关于个人农药接触，只有直接接触农药的妇女才有明显的流产风险（OR = 1.8）。假设在该人群中观察到的总体生殖毒性大部分是雄性介导的事件。为了解决这一问题，需要通过直接测量男性和女性的接触情况来澄清导致生殖毒性的接触事件。
In the current study, there was a modest but significant increase in risk (1.6- to 2-fold) for miscarriages and/or fetal loss occurring throughout the year in the spouses of applicators who use fungicides. There is a surprisingly significant deficit in the number of male children born to the spouses of fungicide applicators. First-trimester miscarriages occur most frequently in the spring, during the time when herbicides are applied, Use of sulfonylurea (odds ratio OR = 2.1), imidizolinone (OR = 2.6) containing herbicides, and the herbicide combination Cheyenne (OR = 2.9) by male applicators was statistically associated with increased miscarriage risk in the spring. Limited survey data from women who are the spouses of applicators did not show major alterations of long-term endocrinologic status (menarche, menopause, endometriosis). With regard to personal pesticide exposures, only women who engaged in pesticide application where there is direct exposure to these products are at demonstrable risk (OR = 1.8) for miscarriage. It was hypothesized that the overall reproductive toxicity observed in this population is, for the greater part, a male-mediated event. Clarification of exposure events leading to reproductive toxicity through direct measurements of exposure in both men and women is needed to resolve this issue.