Added sugars in the diet are positively associated with diastolic blood pressure and triglycerides in children
Added sugars in the diet are positively associated with diastolic blood pressure and triglycerides in children
复制标题
DOI：
10.3945/ajcn.113.076505
复制
发表时间：
2014-07-01
影响因子：
7.1
通讯作者：
Ferndandez, Jose R.
中科院分区：
文献类型：
--
作者：
Kell, Kenneth P.;Cardel, Michelle I.;Ferndandez, Jose R.
背景：传统上，高血压和血脂异常分别与饮食中钠和脂肪的摄入量有关。然而，最近发现它们与成人和年龄较大的青少年摄入添加糖有关，但没有明确的迹象表明这种关联在生命周期的早期表现出来。 目的：本研究探讨了儿童摄入添加糖（食品中非天然存在的糖）、血压 (BP) 和空腹血脂 [甘油三酯和总胆固醇、低密度脂蛋白和高密度脂蛋白 (HDL) 胆固醇]之间的横断面关联。设计：血压、血液血脂和饮食摄入量是在 7-12 岁的多种族儿科样本中获得的，其中包括 122 名欧洲裔美国人 (EA)、106 名非洲裔美国人 (AA)、84 名西班牙裔美国人 (HA) 和 8 名混血儿童，参与种族和种族胰岛素复杂结果混合图 (AMERICO) 研究——一项在阿拉巴马州伯明翰都会区进行的横断面研究，调查种族-民族的影响代谢和健康结果的差异。进行多元回归分析以评估添加糖和钠摄入量与血压的关系以及添加糖和膳食脂肪摄入量与血脂的关系。模型控制了性别、种族、社会经济地位、Tanner 青春期状态、体脂百分比、体力活动和总能量摄入。结果：添加糖与舒张压（P = 0.0462，β = 0.0206）和血清甘油三酯（P = 0.0206，β = 0.1090）呈正相关。钠与血压测量值均无显着相关性，膳食脂肪与血脂也无显着相关性。与 AA 或 EA 儿童相比，HA 儿童的甘油三酯较高，但添加糖消耗量较低。与 EA 或 HA 儿童相比，AA 参与者的血压和 HDL 较高，但甘油三酯较低。结论：这些数据表明，添加糖摄入量的增加可能与儿童的不良心血管健康因素有关，特别是舒张压和甘油三酯升高。识别儿童时期影响心血管健康的饮食因素可以作为降低心血管疾病风险的工具。
Background: Hypertension and dyslipidemia have traditionally been associated with dietary sodium and fat intakes, respectively; however, they have recently been associated with the consumption of added sugars in adults and older adolescents, but there is no clear indication of how early in the life span this association manifests.Objective: This study explored the cross-sectional association between added sugar (sugars not naturally occurring in foods) consumption in children, blood pressure (BP), and fasting blood lipids [triglycerides and total, low-density lipoprotein, and high-density lipoprotein (HDL) cholesterol].Design: BP, blood lipids, and dietary intakes were obtained in a multi-ethnic pediatric sample aged 7-12 y of 122 European American (EA), 106 African American (AA), 84 Hispanic American (HA), and 8 mixed-race children participating in the Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes (AMERICO) study-a cross-sectional study conducted in the Birmingham, AL, metro area investigating the effects of racial-ethnic differences on metabolic and health outcomes. Multiple regression analyses were performed to evaluate the relations of added sugars and sodium intakes with BP and of added sugars and dietary fat intakes with blood lipids. Models were controlled for sex, race-ethnicity, socioeconomic status, Tanner pubertal status, percentage body fat, physical activity, and total energy intake.Results: Added sugars were positively associated with diastolic BP (P = 0.0462, beta = 0.0206) and serum triglycerides (P = 0.0206, beta = 0.1090). Sodium was not significantly associated with either measure of BP nor was dietary fat with blood lipids. HA children had higher triglycerides but lower added sugar consumption than did either the AA or EA children. The AA participants had higher BP and HDL but lower triglycerides than did either the EA or HA children.Conclusions: These data suggest that increased consumption of added sugars may be associated with adverse cardiovascular health factors in children, specifically elevated diastolic BP and triglycerides. Identification of dietary factors influencing cardiovascular health during childhood could serve as a tool to reduce cardiovascular disease risk.