Dual effects of acupuncture on gastric motility in conscious rats
Dual effects of acupuncture on gastric motility in conscious rats
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DOI：
10.1152/ajpregu.00715.2002
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发表时间：
2003-10-01
影响因子：
2.8
通讯作者：
Takahashi, T
中科院分区：
文献类型：
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作者：
Tatewaki, M;Harris, M;Takahashi, T
在35只植入应变传感器的清醒大鼠上观察了手针对胃运动的影响。20只（57.1%）大鼠空腹胃运动无周期性强收缩（A型），15只（42.9%）大鼠空腹胃运动出现移行性复合运动III相样收缩（B型）。针刺胃（ST）-36（足三里）而非背（胃俞、膀胱（BL）-21），可使A型大鼠的收缩峰值增加到基础值的172.4 ± 25.6%（n = 20，P < 0.05）。针刺后60 min运动指数无明显变化。相反，针刺使B型大鼠的最大振幅和运动指数分别下降至72.9 ± 14.0%和73.6 ± 16.2%（n = 15，P < 0.05）。在每种类型中观察到的针刺的刺激和抑制作用在不同的日子是可重复的。在70%的A型大鼠，针刺诱导强烈的III期样收缩持续3小时以上，阿托品，六甲双铵，阿托品甲基溴化物，和迷走神经切断术取消。纳洛酮显著缩短了刺激效应的持续时间，从3.52 ± 0.21小时缩短到1.02 ± 0.15小时（n = 3，P < 0.05）。这些结果表明，针刺ST-36诱导双重效应，刺激或抑制，对胃运动。刺激作用部分通过迷走神经传出和阿片途径介导。
The effects of manual acupuncture on gastric motility were investigated in 35 conscious rats implanted with a strain gauge transducer. Twenty (57.1%) rats showed no cyclic groupings of strong contractions (type A), whereas 15 (42.9%) rats showed the phase III-like contractions of the migrating motor complex (type B) in the fasting gastric motility. Acupuncture at the stomach (ST)-36 (Zusanli), but not on the back [Weishu, bladder (BL)-21], increased the peak amplitude of contractions to 172.4 +/- 25.6% of basal in the type A rats (n = 20, P < 0.05). On the other hand, the motility index for 60 min after the acupuncture was not affected by the acupuncture in this group. On the contrary, acupuncture decreased the peak amplitude and motility index to 72.9 +/- 14.0% and 73.6 +/- 16.2% in the type B rats (n = 15, P < 0.05), respectively. The stimulatory and inhibitory effects of acupuncture observed in each type were reproducible on the separate days. In 70% of type A rats, acupuncture induced strong phase III-like contractions lasting for over 3 h that were abolished by atropine, hexamethonium, atropine methyl bromide, and vagotomy. Naloxone significantly shortened the duration of the stimulatory effects from 3.52 +/- 0.21 to 1.02 +/- 0.15 h (n = 3, P < 0.05). These results suggest that acupuncture at ST-36 induces dual effects, either stimulatory or inhibitory, on gastric motility. The stimulatory effects are mediated in part via vagal efferent and opioid pathways.