Rapid and quantitative detection of hepatitis B virus
Rapid and quantitative detection of hepatitis B virus
复制标题
乙型肝炎病毒快速定量检测
DOI：
10.3748/wjg.v21.i42.11954
复制
发表时间：
2015-11-14
影响因子：
4.3
通讯作者：
Yao, Chun-Yan
中科院分区：
文献类型：
--
作者：
Liu, Yue-Ping;Yao, Chun-Yan
Despite availability of a universal vaccine, hepatitis B virus (HBV) infection has a huge impact on public health worldwide. Accurate and timely diagnosis of HBV infection is needed. Rapid developments have been made in the diagnostic and monitoring methods for HBV infection, including serological and molecular assays. In clinical practice, qualitative hepatitis B surface antigen (HBsAg) testing has long served as a diagnostic marker for individuals infected with HBV. More recently, HBsAg level has been used to predict treatment outcome when determined early during treatment or at baseline. However, identification of HBV DNA positive cases that do not have detectable HBsAg has encouraged the application of molecular tests. Hence, combination of quantitative detection of HBV DNA and HBsAg can be used to discriminate patients during the course of HBV infection and to monitor therapy. This article reviews the most commonly used quantitative methods for HBsAg and HBV DNA.
