Architectural proteins, transcription, and the three-dimensional organization of the genome.
Architectural proteins, transcription, and the three-dimensional organization of the genome.
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DOI：
10.1016/j.febslet.2015.05.025
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发表时间：
2015-10-07
期刊：
影响因子：
3.5
通讯作者：
Corces VG
中科院分区：
文献类型：
--
作者：
Cubeñas-Potts C;Corces VG
结构蛋白介导基因组中远距离序列之间的相互作用。结构蛋白相互作用的两个充分表征的功能包括将增强子拴系到启动子和将含有Polycomb的位点聚集在一起以促进沉默。序列在全基因组范围内相互作用的性质似乎由结构蛋白结合位点的方向以及存在的结构蛋白的数量和身份决定。最终，长距离染色质相互作用导致染色质纤维内形成环。在这篇综述中，我们讨论的数据表明，建筑蛋白质介导的长距离染色质相互作用，既促进和阻碍相邻的相互作用，划分成区域的高度相互作用的染色质结构域的基因组。
Architectural proteins mediate interactions between distant sequences in the genome. Two well-characterized functions of architectural protein interactions include the tethering of enhancers to promoters and bringing together Polycomb-containing sites to facilitate silencing. The nature of which sequences interact genome-wide appears to be determined by the orientation of the architectural protein binding sites as well as the number and identity of architectural proteins present. Ultimately, long range chromatin interactions result in the formation of loops within the chromatin fiber. In this review, we discuss data suggesting that architectural proteins mediate long range chromatin interactions that both facilitate and hinder neighboring interactions, compartmentalizing the genome into regions of highly interacting chromatin domains.