Total synthesis of clavosolide A
Total synthesis of clavosolide A
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DOI：
10.1016/j.tet.2008.03.039
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发表时间：
2008-05-26
期刊：
影响因子：
2.1
通讯作者：
Gajula, Praveen Kumar
中科院分区：
文献类型：
--
作者：
Chakraborty, Tushar Kanti;Reddy, Vakiti Ramkrishna;Gajula, Praveen Kumar
对于本文所述的 (-)-clavosolide A 的全合成，施密特糖苷化反应用于在合成的早期阶段将糖部分连接到分子的取代四氢吡喃单元的 4-羟基上，其本身是按照我们之前开发的 Ti(III) 介导的方法构建的，最后，山口反应成功地用于分子的两半的环二聚化，从而得到其总分子合成。 (c) 2008 Elsevier Ltd. 保留所有权利。
For the total synthesis of (-)-clavosolide A described herein, a Schmidt glycosidation reaction was used to attach the sugar moiety at an early stage in the synthesis to the 4-hydroxy group of the substituted tetrahydropyran unit of the molecule, which itself was built following a Ti(III)-mediated method developed by us earlier, and at the end, it was the Yamaguchi reaction that was successfully employed for the cyclodimerization of the two halves of the molecule leading to its total synthesis. (c) 2008 Elsevier Ltd. All rights reserved.