Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.
Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.
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头颈癌的预后因素：意大利单一机构的10年回顾性分析。
DOI：
10.14639/0392-100x-1246
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发表时间：
2017-12
期刊：
影响因子：
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通讯作者：
Boccia S
中科院分区：
文献类型：
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作者：
Cadoni G;Giraldi L;Petrelli L;Pandolfini M;Giuliani M;Paludetti G;Pastorino R;Leoncini E;Arzani D;Almadori G;Boccia S
本研究旨在评估首次原发性头颈癌（HNC）患者的人口统计学、生活习惯和临床数据与总生存期（OS）、复发和第二原发癌（SPC）之间的相关性。我们回顾性分析了2002-2012年间在罗马“Agostino Gemelli”教学医院接受原发性HNC治疗的482例患者的数据。使用风险比（HR）和95%置信区间（CI）评价个体参数与特定结局（如OS、癌症复发和第二原发癌（SPC）外观）的相关性。所有HNC病例的5年OS为60.6%，口腔为49.0%，口咽部为54.8%，下咽部为50.0%，喉为63.4%。OS的预测因素为年龄较大（HR = 1.04; 95% CI：1.02-1.05）和晚期肿瘤分期（HR = 2.00; 95% CI：1.41-2.84）。复发的风险与每周饮酒8-14次有关（HR = 1.73; 95%CI：1.00-2.97）。发生SPC的风险随着肿瘤分期的进展而增加（HR = 2.75; 95%CI：1.39-5.44），并且随着吸烟超过40年而增加（HR = 3.68; 95%CI：1.10-12.30）。HNC研究中心的OS不同。年龄增加是HNC OS的不利预测因素。肿瘤分期是OS和发展SPC风险的预后因素。饮酒和吸烟分别是复发和SPC的预后因素。
This study was undertaken to evaluate the association between demographics, lifestyle habits, and clinical data and overall survival (OS), recurrence and second primary cancer (SPC) in patients with first primary head and neck cancer (HNC). We retrospectively reviewed data from 482 patients treated at the "Agostino Gemelli" Teaching Hospital, Rome, between 2002-2012 for primary HNC. Individual parameters were evaluated for association with specific outcomes such as OS, cancer recurrence and second primary cancer (SPC) appearance using hazard ratios (HR) and 95% confidence intervals (CIs). Five-year OS was 60.6% for all HNC cases, 49.0% for oral cavity, 54.8% for oropharynx, 50.0% for hypopharynx and 63.4% for larynx. Predictors of OS were older age (HR = 1.04; 95% CI: 1.02-1.05) and advanced tumour stage (HR = 2.00; 95% CI: 1.41-2.84). The risk of recurrence was associated with drinking 8-14 drinks per week (HR = 1.73; 95% CI: 1.00-2.97). The risk of developing SPC increased with advanced tumour stage (HR = 2.75; 95% CI: 1.39-5.44) and with smoking for more than 40 years (HR = 3.68; 95% CI: 1.10-12.30). OS differed among HNC sites. Increasing age was an unfavourable predictor of HNC OS. Tumour stage was a prognostic factor both for OS and for risk of developing SPC. Alcohol and tobacco consumption were prognostic factors for recurrence and SPC, respectively.