The gastrin-releasing peptide system in the spinal cord mediates masculine sexual function
The gastrin-releasing peptide system in the spinal cord mediates masculine sexual function
复制标题
脊髓中的胃泌素释放肽系统介导男性性功能
DOI：
10.1007/s12565-010-0097-z
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发表时间：
2011
影响因子：
1.2
通讯作者：
H. Sakamoto
中科院分区：
文献类型：
--
作者：
Sakamoto T;Mori C;Minami S;Takahashi H;et al;H. Sakamoto
腰椎节段特别令人感兴趣，因为它们是性二型的，并且包含几个神经元回路，这些神经元回路在引起男性性反应如勃起和射精中很重要。胃泌素释放肽（GRP）是最早从猪胃中分离到的蛙皮素样肽家族的一员。雄性大鼠腰髓（L3-L4水平）中的神经元集合投射到下腰髓（L5-L 6水平），将GRP释放到已知调节雄性性反射的躯体和自主神经中枢。所有这些靶神经元表达并定位GRP的特异性受体。该系统的GRP神经元是性二态的，是突出的雄性大鼠，但在女性的退化。在雄激素受体基因功能障碍的XY大鼠中，该系统是完全女性化的，表明了二型性的雄激素依赖性。药理学刺激GRP受体在这一脊髓区域显着恢复性反射去势雄性大鼠。雄性大鼠暴露于严重的创伤应激会降低腰椎脊髓中GRP的局部含量和轴突分布，并导致体内阴茎反射衰减。给予GRP受体特异性激动剂可恢复创伤应激暴露的雄性大鼠阴茎反射。本文综述了最近发现的脊髓GRP系统，这可能是容易受到压力，控制男性生殖功能的研究结果。男性特异性神经系统调节性功能的鉴定为男性生殖功能障碍的潜在治疗方法提供了新的途径。
The lumbar spinal segments are of particular interest because they are sexually dimorphic and contain several neuronal circuits that are important in eliciting male sexual responses such as erection and ejaculation. Gastrin-releasing peptide (GRP) is a member of the bombesin-like peptide family first isolated from the porcine stomach. A collection of neurons in the lumbar spinal cord (L3–L4 level) of male rats projects to the lower lumbar spinal cord (L5–L6 level), releasing GRP onto somatic and autonomic centers known to regulate male sexual reflexes. All these target neurons express and localize specific receptors for GRP. This system of GRP neurons is sexually dimorphic, being prominent in male rats but vestigial in females. The system is completely feminine in genetically XY rats with a dysfunctional androgen receptor gene, demonstrating the androgen-dependent nature of the dimorphism. Pharmacological stimulation of GRP receptors in this spinal region remarkably restores sexual reflexes in castrated male rats. Exposure of male rats to a severe traumatic stress decreases the local content and the axonal distribution of GRP in the lumbar spinal cord and results in an attenuation of penile reflexes in vivo. Administration of a specific agonist for GRP receptors restores penile reflexes in the traumatic stress-exposed male rats. This review summarizes findings on this recently identified spinal GRP system, which may be vulnerable to stress, that controls male reproductive function. The identification of a male-specific neuronal system regulating sexual functions offers new avenues for potential therapeutic approaches to masculine reproductive dysfunction.