Fibronectin in parasitic diseases.
Fibronectin in parasitic diseases.
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纤连蛋白在寄生虫病中的作用。
DOI：
10.1093/clinids/9.supplement_4.s391
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Wyler,DJ
中科院分区：
文献类型：
--
作者：
Wyler,DJ
纤连蛋白是一种重要的间质基质蛋白，具有多种分子结合位点和多种生物学活性，在某些寄生虫病中可能发挥重要作用，利什曼原虫和克氏锥虫可与宿主纤连蛋白结合，从而促进它们与宿主细胞的结合。侵袭性溶组织内阿米巴和血吸虫产生降解纤维连接蛋白和其他基质蛋白的蛋白酶，可能促进肠粘膜和皮肤屏障的破坏以防止感染。肉芽肿性炎症伴随着卵裂体的组织沉积，促进了过量基质的产生和瘢痕的形成。肉芽肿巨噬细胞和成纤维细胞分泌纤连蛋白，其可用于募集额外的成纤维细胞，并且还可有助于维持肉芽肿的结构完整性。这些早期的发现表明，寄生虫-纤连蛋白的相互作用可能是一个肥沃的领域进行进一步的研究。
Fibronectin, a major interstitial matrix protein with binding sites for a variety of molecules and with multiple biologic activities, may play an important role in certain parasitic diseases.LeishmaniaandTrypanosoma cruzibind host fibronectin, which, in turn, facilitates their association with the cells they parasitize. InvasiveEntamoeba histolyticaandSchistosomaproduce proteases that degrade fibronectin and other matrix proteins, presumably facilitating the breaching of intestinal mucosa and dermal barriers to infection. The granulomatous inflammation that accompanies tissue deposition of schistosomal eggs promotes excess matrix production and scar formation. Granuloma macrophages and fibroblasts secrete fibronectin, which may serve to recruit additional fibroblasts and also may aid in maintaining the structural integrity of the granulomas. These early findings suggest that parasite-fibronectin interactions may be a fertile area for further research.