Unsaturated fatty acids and insulin resistance in childhood obesity
Unsaturated fatty acids and insulin resistance in childhood obesity
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DOI：
10.1515/jpem-2013-0281
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发表时间：
2014-05-01
影响因子：
1.4
通讯作者：
Bustos, Paulina
中科院分区：
文献类型：
--
作者：
Toledo, Karen;Aranda, Mario;Bustos, Paulina
目的：肥胖的特征是血浆游离脂肪酸（FFA）水平升高，干扰胰岛素信号传导。本研究的目的是评估FFA在肥胖儿童和青少年的配置文件，并确定其与不同程度的insulinresistance.Methods：一个横向研究进行了51名儿童和青少年（平均年龄，11.7 +/- 1.6岁，47%的男性）与肥胖（体重指数>= 95百分位数）。人体测量，临床和生化参数进行了评估。采用稳态模型胰岛素抵抗指数（HOMA-IR）测定胰岛素抵抗。采用高效液相色谱法，以十七烷酸为内标物，对血浆脂肪酸进行定量分析。肉豆蔻酸、亚油酸、棕榈酸、油酸、硬脂酸和总脂肪酸的平均浓度分别为9.3 ± 2.2、86.5 ± 38.3、93.0 ± 35.5、177.0 ± 83.6，48.5 ± 14.9和414.3 ± 160.9 μ mol/L。总脂肪酸和不饱和脂肪酸如油酸、亚油酸与胰岛素抵抗呈显著负相关。高胰岛素抵抗（HOMA-IR >2.5）的儿童与HOMA-IR>2.5的儿童相比，
Objective: Obesity is characterized by increased levels of plasma free fatty acids (FFAs) that interfere with insulin signaling. The aim of our study was to assess the FFA profile in obese children and adolescents and to determine their relation with different degrees of insulin resistance.Methods: A transversal study was conducted of 51 children and adolescents (mean age, 11.7 +/- 1.6 years; 47% males) with obesity (body mass index >= 95 percentile). Anthropometric, clinical, and biochemical parameters were assessed. Insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR) index. Plasma fatty acids were quantified by high-performance liquid chromatography with heptadecanoic acid as the internal standard.Results: The mean concentration of myristic acid, linoleic acid, palmitic acid, oleic acid, stearic acid, and total fatty acids was 9.3 +/- 2.2, 86.5 +/- 38.3, 93.0 +/- 35.5, 177.0 +/- 83.6, 48.5 +/- 14.9, and 414.3 +/- 160.9 mu mol/L, respectively. Total fatty acids and unsaturated fatty acids such as oleic acid and linoleic acid showed an inverse significant correlation with insulin resistance. Children with high insulin resistance (HOMA-IR >2.5) showed a decrease in unsaturated fatty acids compared with children having a HOMA-IR of