Use of porcine small intestinal submucosal graft in the surgical management of tunical deficiencies with penile prosthetic surgery
Use of porcine small intestinal submucosal graft in the surgical management of tunical deficiencies with penile prosthetic surgery
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DOI：
10.1016/s0090-4295(02)01607-2
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发表时间：
2002-05-01
期刊：
影响因子：
2.1
通讯作者：
Knoll, LD
中科院分区：
文献类型：
--
作者：
Knoll, LD
目标。报告使用新型无细胞异种猪空肠粘膜下移植物作为阴茎假体插入后白膜缺陷（远端糜烂、衰减）的闭合材料。方法。 17 名具有至少 36 个月留置三件式充气阴茎假体病史的患者出现白膜缺陷。九名单侧远端被膜侵蚀的患者和八名被膜变薄的患者接受了阴茎假体修正手术和使用冻干小肠粘膜下层的被膜重建（Surgisis）。重建技术采用耻骨上和冠状下切口方法以及新型三件式充气假体。结果。所有 17 名患者均通过重建手术矫正了外膜缺损。平均随访 21 个月（范围 6 至 34 个月），没有患者出现移植物与被膜分离或缺陷复发的情况。所有患者都有功能满意的假肢。移植部位未出现感染、疼痛、肿胀或局部炎症反应的迹象。没有患者需要任何额外的手术。结论。在最初的长期随访中，用无细胞猪空肠粘膜下移植物通过阴茎假体手术来覆盖外膜缺陷，可以获得令人满意的临床结果。易于手术操作和放置，消除了不可吸收的合成移植材料，并且没有移植物收获技术带来的相关合并症，再加上没有不良反应，使该移植物成为解剖学和功能性外膜替代品。 (C) 2002，爱思唯尔科学公司。
Objectives. To report the use of a new acellular xenographic porcine jejunal submucosal graft as a closure material for tunica albuginea deficiencies (distal erosion, attenuation) after penile prosthesis insertion.Methods. Seventeen patients with at least a 36-month history of having an indwelling three-piece inflatable penile prosthesis developed tunica albuginea deficiencies. Nine patients with unilateral distal erosion of the tunica and eight with attenuation of the tunica underwent penile prosthesis revisionary surgery and tunical reconstruction using lyophilized small intestinal submucosa (Surgisis). The reconstructive techniques used a suprapubic and subcoronal incisional approach and a new three-piece inflatable prosthesis.Results. Reconstructive surgical correction of the tunical defect was achieved in all 17 patients. At a mean follow-up of 21 months (range 6 to 34), no patient had had separation of the graft from the tunica or recurrence of the deficiency. All patients had a satisfactorily functioning prosthesis. Infection, pain, bulging, or evidence of a local inflammatory response at the graft site has not occurred. No patient required any additional surgery.Conclusions. At the initial long-term follow-up, acellular porcine jejunal submucosal grafts for coverage of tunical deficiencies with penile prosthetic surgery allow for satisfactory clinical results. The ease of surgical handling and placement, elimination of nonabsorbable synthetic grafting materials, and no associated comorbidities from graft harvesting techniques, coupled with no adverse reactions, make this graft an anatomic and functional tunical substitute. (C) 2002, Elsevier Science Inc.