Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: An autopsy series
Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: An autopsy series
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DOI：
10.1016/j.burns.2009.11.007
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发表时间：
2010-09-01
期刊：
影响因子：
2.7
通讯作者：
Wolf, Steven E.
中科院分区：
文献类型：
--
作者：
D'Avignon, Laurie C.;Hogan, Brian K.;Wolf, Steven E.
细菌感染是烧伤患者死亡的常见原因，病毒感染，特别是单纯疱疹病毒（HSV）和巨细胞病毒（CMV）也与死亡有关。这项研究是对美国陆军研究所（USAISR）烧伤科12年来治疗的严重热烧伤患者的所有尸检报告的回顾性审查。该综述集中于那些通过尸检报告归因于细菌或病毒原因的死亡患者。在3751例住院患者中，228例死亡，97例进行尸检。27例患者的死亡归因于细菌，5例患者归因于病毒。与死亡率相关的细菌病原体包括铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌和金黄色葡萄球菌。这种与死亡率的相关性与烧伤总表面积%、全层烧伤%、吸入性损伤和烧伤后死亡天数无关。血流感染是细菌相关死亡的最常见原因（50%），其次是肺炎（44%）和伤口感染（6%）。烧伤后死亡时间
Bacterial infections are a common cause of mortality in burn patients and viral infections, notably herpes simplex virus (HSV) and cytomegalovirus (CMV) have also been associated with mortality. This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit over 12 years. The review focused on those patients with death attributed to a bacterial or viral cause by autopsy report. Of 3751 admissions, 228 patients died with 97 undergoing autopsy. Death was attributed to bacteria for 27 patients and to virus for 5 patients. Bacterial pathogens associated with mortality included Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. This association with mortality was independent of % total body surface area burn, % full-thickness burn, inhalation injury, and day of death post-burn. Bloodstream infection was the most common cause of bacteria related death (50%), followed by pneumonia (44%) and wound infection (6%). Time to death following burn was