Validity of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma A Retrospective Pathology-Matched Study
Validity of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Pretreatment Evaluation of Patients With Cervical Carcinoma A Retrospective Pathology-Matched Study
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DOI：
10.1097/igc.0000000000000287
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发表时间：
2014-11-01
影响因子：
4.8
通讯作者：
Wu, Sufang
中科院分区：
文献类型：
--
作者：
Dong, Yu;Wang, Xiaoyun;Wu, Sufang
目的：本研究的目的是评估F-18-氟脱氧葡萄糖（F-18-FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）的有效性为术前评估宫颈癌patients with cervical carcinoma.Methods：回顾性评价63例患者，诊断为IA-IIA期宫颈癌术前进行F-18-FDG PET/CT，进行。计算PET/CT预测宫颈、阴道、子宫体和手术标本淋巴结浸润阳性的敏感性、特异性、阳性预测值、阴性预测值和似然比。PET/CT检测阳性手术标本的敏感性、特异性、阳性预测值和阴性预测值分别为88.2%、75%，93.8%和60%。LR+比率为3.5，LR-比率为0.2。PET/CT诊断阳性手术标本的敏感性、特异性、阳性预测值和阴性预测值分别为100%、70.97%、5.3%和100%。LR+比率为3.4，LR-比率为0。PET/CT诊断阳性手术标本的敏感性、特异性、阳性预测值和阴性预测值分别为75%、83.1%、23.1%和98%。LR+比率为4.4，LR-比率为0.3。PET/CT检查阳性淋巴结浸润诊断阳性手术标本的敏感性、特异性、阳性预测值和阴性预测值分别为87.5%、78.4%、38.9%和97.6%。LR+比值为4.1，LR-比值为0.2。结论：宫颈受侵、宫体受侵阴性、淋巴结受侵阴性是F18 FDGPET/CT的有效征象。
Objective: The aim of this study was to evaluate the validity of F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET)/computed tomography (CT) for pretreatment evaluation of patients with cervical carcinoma.Methods: Retrospective evaluation of 63 patients, diagnosed with stage IA-IIA cervical carcinoma who underwent F-18-FDG PET/CT before surgery, was performed. Sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratios (LRs) of PET/CT for predicting the positive cervix, vagina, uterine body, and lymph node invasion at the surgical specimen was calculated.Results: Sensitivity, specificity, positive predictive value, and negative predictive value of the positive cervix invasion in PET/CT to detect positive surgical specimen were 88.2%, 75%, 93.8%, and 60%, respectively. The LR+ ratio was 3.5, and the LR- ratio was 0.2. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive vagina invasion in PET/CT to detect positive surgical specimen were 100%, 70.97%, 5.3%, and 100%, respectively. The LR+ ratio was 3.4, and the LR- ratio was 0. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive uterine body invasion in PET/CT to detect positive surgical specimen were 75%, 83.1%, 23.1%, and 98%, respectively. The LR+ ratio was 4.4, and the LR- ratio was 0.3. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive lymph node invasion in PET/CT to detect positive surgical specimen were 87.5%, 78.4%, 38.9%, and 97.6%, respectively. The LR+ ratio was 4.1, and the LR- ratio was 0.2.Conclusions: The cervix invasion, negative uterine body invasion, and negative lymph node invasion are effective F-18-FDG PET/CT findings.