Mechanisms underlying rapid experience-dependent plasticity in the human visual cortex
Mechanisms underlying rapid experience-dependent plasticity in the human visual cortex
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DOI：
10.1073/pnas.251357198
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发表时间：
2001-12-04
影响因子：
11.1
通讯作者：
Cohen, LG
中科院分区：
文献类型：
--
作者：
Boroojerdi, B;Battaglia, F;Cohen, LG
视觉剥夺会导致视觉皮层兴奋性迅速增加，这可能会导致动物更好地巩固空间记忆，并降低人类的视觉识别阈值。在动物研究中，γ-氨基丁酸 (GABA) 能、N-甲基-D-天冬氨酸 (NMDA) 和胆碱能受体被认为与视觉皮层可塑性有关。在这里，我们使用药理学方法，发现劳拉西泮（通过充当正变构调节剂来增强 GABAA 受体功能）、右美托芬（NMDA 受体拮抗剂）和东莨菪碱（毒蕈碱受体拮抗剂）可阻止与光剥夺相关的快速塑性变化。这些发现表明 GABA、NMDA 和胆碱能受体参与人类视觉皮层的快速经验依赖性可塑性。
Visual deprivation induces a rapid increase in visual cortex excitability that may result in better consolidation of spatial memory in animals and in lower visual recognition thresholds in humans. gamma -Aminobutyric acid (GABA)ergic, N-methyl-D-aspartate (NMDA), and cholinergic receptors are thought to be involved in visual cortex plasticity in animal studies. Here, we used a pharmacological approach and found that lorazepam (which enhances GABAA receptor function by acting as a positive allosteric modulator), dextrometorphan (NMDA receptor antagonist), and scopolamine (muscarinic receptor antagonist) blocked rapid plastic changes associated with light deprivation. These findings suggest the involvement of GABA, NMDA, and cholinergic receptors in rapid experience-dependent plasticity in the human visual cortex.