The incidence of cardiovascular morbidity among patients with bipolar disorder: A population-based longitudinal study in Ontario, Canada
The incidence of cardiovascular morbidity among patients with bipolar disorder: A population-based longitudinal study in Ontario, Canada
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DOI：
10.1016/j.jad.2009.06.029
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发表时间：
2010-04-01
影响因子：
6.6
通讯作者：
Khizar, Anbreen
中科院分区：
文献类型：
--
作者：
Callaghan, Russell C.;Khizar, Anbreen
背景资料：尽管双相情感障碍患者的心血管危险因素发生率很高，但对这一人群心血管疾病的发病率知之甚少。根据2002年4月1日至2006年3月31日期间加拿大安大略的出院记录，我们构建了一项基于人群的队列研究，以评估诊断为双相情感障碍的个体是否（n = 5999）与接受阑尾炎初步诊断的个体的匹配人群代表组相比，具有显著更大的随后因心血管疾病再入院的风险。使用考克斯回归程序估计心血管相关诊断的再入院时间的组间差异。结果：与阑尾炎组相比，双相情感障碍组因心血管事件再入院的校正风险显著更高[校正风险比（AHR）= 1.66，95%CI，1.37-2.07，p
Background: Despite the high rates of cardiovascular risk factors among people with bipolar disorder, little is known about the incidence of cardiovascular morbidity in this population.Methods: Based upon Ontario, Canada hospital discharge records from April 1, 2002 to March 31, 2006, we constructed a population-based cohort study to assess whether individuals diagnosed with bipolar disorder (n = 5999) would have a significantly greater risk of subsequent readmission with a cardiovascular condition in comparison to a matched population-proxy group of individuals receiving an appendicitis primary diagnosis. A Cox regression procedure was used to estimate group differences in time-to-readmission with a cardiovascular-related diagnosis. Patients were followed for a period up to 4 years.Results: The bipolar disorder group had a significantly greater adjusted risk of readmission for a cardiovascular event in comparison to individuals in the appendicitis group [adjusted hazard ratio (AHR) = 1.66, 95% CI, 1.37-2.07, p