Therapeutic vaccines for substance dependence.
Therapeutic vaccines for substance dependence.
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DOI：
10.1586/14760584.3.1.11
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发表时间：
2004-02-01
影响因子：
6.2
通讯作者：
Kosten, Thomas R
中科院分区：
文献类型：
--
作者：
Haney, Margaret;Kosten, Thomas R
免疫疗法正在开发中，作为治疗物质依赖的新方法。目前正在使用这种新方法测试的滥用药物包括尼古丁、可卡因、苯环己哌啶和甲基苯丙胺。在实验动物模型中，一系列免疫疗法，包括疫苗、单克隆抗体和催化抗体，已被证明可以减少药物寻求。在人体临床试验中，可卡因和尼古丁疫苗已被证明可以诱导抗体滴度，同时产生很少的副作用。人体研究正在进行中，以确定这些疫苗如何与其目标药物结合相互作用。总体而言，免疫疗法提供了一系列潜在的治疗选择：药物治疗以及药物过量治疗、预防脑或心脏毒性以及怀孕药物滥用者的胎儿保护。
Immunotherapies are under development as a new approach to the treatment of substance dependence. The drugs of abuse currently being tested using this new approach are nicotine, cocaine, phencyclidine and methamphetamine. In laboratory animal models, a range of immunotherapies, including vaccines, monoclonal antibodies and catalytic antibodies, have been shown to reduce drug seeking. In human clinical trials, cocaine and nicotine vaccines have been shown to induce antibody titers while producing few side effects. Studies in humans determining how these vaccines interact in combination with their target drug are underway. Overall, immunotherapy offers a range of potential treatment options: drug treatment, as well as the treatment of overdose, prevention of brain or cardiac toxicity and fetal protection in pregnant drug abusers.