Central and peripheral hemodynamic responses to passive limb movement: the role of arousal.
Central and peripheral hemodynamic responses to passive limb movement: the role of arousal.
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对被动肢体运动的中枢和外周血流动力学反应：唤醒的作用。
DOI：
10.1152/ajpheart.00851.2011
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Richardson,RS
中科院分区：
文献类型：
--
作者：
Venturelli,Massimo;Amann,M;McDaniel,J;Trinity,JD;Fjeldstad,AS;Richardson,RS
觉醒在人类被动肢体运动的中枢和外周血流动力学反应中的确切作用尚不清楚，但已被认为是一个潜在的贡献者。因此，我们使用了一个没有下肢传入反馈的人体模型来确定唤醒对被动腿部运动的血流动力学反应的作用。在9名脊髓损伤患者中，我们比较了有和没有视觉反馈（分别为M+VF和M-VF）的单腿被动膝关节伸展的中枢和外周血流动力学和痉挛反应，以及在没有运动或视觉反馈但有运动感知的第三次试验中（F）。在三种方案中评价通气量（V_e）、心率、每搏输出量、心输出量、平均动脉压和腿部血流量（LBF）。在M+VF（55 ± 11%）、M-VF（63 ± 13%）和F（48 ± 12%）试验中，V从基线迅速增加。所有试验的中心血流动力学（心率、每搏输出量、心输出量和平均动脉压）均未发生变化。在M+VF方案中，LBF较基线增加126 ± 18 ml/min，在M-VF方案中增加109 ± 23 ml/min，但在F方案中无变化。因此，通过使用没有来自腿部的传入反馈的模型，本研究的结果表明，尽管唤醒是由被动运动或被动运动的想法引起的，如通过V_e的增加所证明的，但是这种增加的神经活动没有中枢或外周血液动力学影响。此外，这项研究表明，中枢血流动力学反应不是运动诱导的LBF的必要组成部分。
The exact role of arousal in central and peripheral hemodynamic responses to passive limb movement in humans is unclear but has been proposed as a potential contributor. Thus, we used a human model with no lower limb afferent feedback to determine the role of arousal on the hemodynamic response to passive leg movement. In nine people with a spinal cord injury, we compared central and peripheral hemodynamic and ventilatory responses to one-leg passive knee extension with and without visual feedback (M+VF and M-VF, respectively) as well as in a third trial with no movement or visual feedback but the perception of movement (F). Ventilation (V̇e), heart rate, stroke volume, cardiac output, mean arterial pressure, and leg blood flow (LBF) were evaluated during the three protocols. V̇eincreased rapidly from baseline in M+VF (55 ± 11%), M-VF (63 ± 13%), and F (48 ± 12%) trials. Central hemodynamics (heart rate, stroke volume, cardiac output, and mean arterial pressure) were unchanged in all trials. LBF increased from baseline by 126 ± 18 ml/min in the M+VF protocol and 109 ± 23 ml/min in the M-VF protocol but was unchanged in the F protocol. Therefore, with the use of model that is devoid of afferent feedback from the legs, the results of this study reveal that, although arousal is invoked by passive movement or the thought of passive movement, as evidenced by the increase in V̇e, there is no central or peripheral hemodynamic impact of this increased neural activity. Additionally, this study revealed that a central hemodynamic response is not an obligatory component of movement-induced LBF.