Immunization for Ebola virus infection
Immunization for Ebola virus infection
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DOI：
10.1038/nm0198-037
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发表时间：
1998-01-01
期刊：
影响因子：
82.9
通讯作者：
Nabel, GJ
中科院分区：
文献类型：
--
作者：
Xu, L;Sanchez, A;Nabel, GJ
埃博拉病毒感染会导致迅速进展，往往是致命的，发烧，出血和低血压症状。之前为引起对这种疾病的保护性免疫而进行的尝试尚未成功。我们在这里报告，保护免受埃博拉病毒的致命影响，可以在动物模型中实现免疫与编码病毒蛋白质的质粒。我们分析了对病毒核蛋白（NP）和糖蛋白（sGP或GP）的分泌或跨膜形式的免疫应答，以及它们在与人类疾病类似的豚鼠感染模型中保护免受感染的能力。实现了保护，并且与抗体滴度和对sGP或GP的抗原特异性T细胞应答相关。因此，可以通过基因疫苗接种开发对埃博拉病毒的免疫力，并可能有助于限制这种疾病的传播。
Infection by Ebola virus causes rapidly progressive, often fatal, symptoms of fever, hemorrhage and hypotension. Previous attempts to elicit protective immunity for this disease have not met with success. We report here that protection against the lethal effects of Ebola virus can be achieved in an animal model by immunizing with plasmids encoding viral proteins. We analyzed immune responses to the viral nucleoprotein (NP) and the secreted or transmembrane forms of the glycoprotein (sGP or GP) and their ability to protect against infection in a guinea pig infection model analogous to the human disease. Protection was achieved and correlated with antibody titer and antigen-specific T-cell responses to sGP or GP. Immunity to Ebola virus can therefore be developed through genetic vaccination and may facilitate efforts to limit the spread of this disease.