Surface interaction and behavior of poly(amidoamine) dendrimers: deformability and lipid bilayer disruption.
Surface interaction and behavior of poly(amidoamine) dendrimers: deformability and lipid bilayer disruption.
复制标题
聚（胺）树突聚合物的表面相互作用和行为：变形性和脂质双层破坏。
DOI：
10.1166/jctn.2009.1189
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发表时间：
2009-07-01
影响因子：
--
通讯作者：
Baker JR Jr
中科院分区：
文献类型：
--
作者：
Majoros IJ;Williams CR;Becker AC;Baker JR Jr
Dendrimers are synthetically built macromolecules that, through the conjugation of various functional moieties, have become the basis of the emerging field of nanomedicine. However, research is beginning to show that the dynamic interactions between PAMAM dendrimers and cellular lipid membranes can stimulate membrane hole formation and expansion. These membrane disruptions are not unique to dendrimers and are the observed functions of natural proteins such as MSI-78 (pexiganan) and Trans-Activator of Transcription protein (TAT). Membrane interactions can also affect the dendrimers, causing structural deformations and encapsulation within a lipid bilayer vesicle. Acetamide capping of the positively charged PAMAM terminal end groups neutralizes the dendrimer, and many of these effects can be minimized or eliminated. Knowledge gained from these studies will indeed have an impact on the future designs of dendrimer-based nanodevices.
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影响因子：
3.9
作者：
Betley, TA;Holl, MMB;Baker, JR
通讯作者：
Baker, JR
影响因子：
3.4
作者：
JOHNSON, SJ;BAYERL, TM;SACKMANN, E
通讯作者：
SACKMANN, E
影响因子：
1.8
作者：
Mecke, A;Lee, I;Orr, BG
通讯作者：
Orr, BG
影响因子：
4.7
作者：
Hong, SP;Bielinska, AU;Holl, MMB
通讯作者：
Holl, MMB
影响因子：
4.8
作者：
Moore, VD;Payne, RM
通讯作者：
Payne, RM