Ribosomal proteins in cell proliferation and apoptosis.
Ribosomal proteins in cell proliferation and apoptosis.
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DOI：
10.3109/08830189909088492
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发表时间：
1999-01-01
影响因子：
5
通讯作者：
Ioannou, Y A
中科院分区：
文献类型：
--
作者：
Chen, F W;Ioannou, Y A
核糖体蛋白具有协调蛋白质生物合成以维持细胞稳态和存活的复杂任务。最近的证据表明，许多核糖体蛋白质具有独立于它们参与蛋白质生物合成的次要功能。这些蛋白质中的许多作为细胞增殖调节剂起作用，并且在某些情况下作为细胞死亡的诱导剂。具体而言，人核糖体蛋白L13 a的表达已显示诱导细胞凋亡，推测是通过在细胞周期的G2/M期阻滞细胞生长。此外，抑制L13 a的表达诱导靶细胞的凋亡，表明该蛋白是细胞存活所必需的。在酵母酿酒酵母中也得到了类似的结果，其中通过同源重组使L13 a、rp 22和rp 23的酵母同系物失活导致严重的生长迟缓和死亡。此外，一个密切相关的核糖体蛋白，L7，逮捕细胞在G1期，也诱导细胞凋亡。因此，一组核糖体蛋白可能作为细胞周期检查点，并组成一个新的细胞增殖调节因子家族。
Ribosomal proteins have the complex task of coordinating protein biosynthesis to maintain cell homeostasis and survival. Recent evidence suggests that a number of ribosomal proteins have secondary functions independent of their involvement in protein biosynthesis. A number of these proteins function as cell proliferation regulators and in some instances as inducers of cell death. Specifically, expression of human ribosomal protein L13a has been shown to induce apoptosis, presumably by arresting cell growth in the G2/M phase of the cell cycle. In addition, inhibition of expression of L13a induces apoptosis in target cells, suggesting that this protein is necessary for cell survival. Similar results have been obtained in the yeast Saccharomyces cerevisiae, where inactivation of the yeast homologues of L13a, rp22 and rp23, by homologous recombination results in severe growth retardation and death. In addition, a closely related ribosomal protein, L7, arrests cells in G1 and also induces apoptosis. Thus, it appears that a group of ribosomal proteins may function as cell cycle checkpoints and compose a new family of cell proliferation regulators.