Electrophysiological responses from intrinsically photosensitive retinal ganglion cells are diminished in glaucoma patients.
Electrophysiological responses from intrinsically photosensitive retinal ganglion cells are diminished in glaucoma patients.
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DOI：
10.1016/j.optom.2016.07.004
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发表时间：
2017-10
影响因子：
2.3
通讯作者：
Ayaki M
中科院分区：
文献类型：
--
作者：
Kuze M;Morita T;Fukuda Y;Kondo M;Tsubota K;Ayaki M
记录青光眼患者视网膜内光敏神经节细胞（ipRGC）的视网膜电图（ERG）。本文对10例正常人和15例青光眼患者进行了ERG检查。ERG照明系统的构建是为了实现受体沉默取代，并且包括光学漫射器和四合一发光二极管。来自正常受试者的ipRGC的ERG记录显示“开”反应和“关”反应。正常人的开和关反应的平均内隐时间分别为103.0 ± 24.9和337.9 ± 45.8 ms，相应的振幅分别为7.7 ± 2.8和7.3 ± 3.4 μV。青光眼患者的开和关反应的内隐时间分别为135.0 ± 28.9和368.2 ± 17.3ms。相应的开、关反应幅度分别为0.47 ± 0.18和0.66 ± 0.32 μV。结果表明，成功的ERG记录的ipRGC从先进的青光眼患者，具有显着降低的幅度，虽然不是隐式时间，与正常受试者相比。
To record electroretinograms (ERGs) from intrinsically photosensitive retinal ganglion cells (ipRGCs) of glaucoma patients. ERGs were recorded in 10 normal subjects and 15 patients with glaucoma. The ERG illumination system was built to achieve receptor-silent substitution, and comprised an optical diffuser and four-in-one light-emitting diodes. The ERG recordings of ipRGC from normal subjects showed an “on” response and an “off” response. The mean (±SD) implicit time for the on and off responses in normal subjects was 103.0 ± 24.9 and 337.9 ± 45.8 ms, respectively, with corresponding amplitudes of 7.7 ± 2.8 and 7.3 ± 3.4 μV, respectively. In glaucoma patients, the implicit time of the on and off responses was 135.0 ± 28.9 and 368.2 ± 17.3 ms, respectively. The corresponding amplitudes of the on and off responses in these patients were 0.47 ± 0.18 and 0.66 ± 0.32 μV, respectively. The results demonstrate successful ERG recording of ipRGCs from advanced glaucoma patients, with marked reductions in amplitude, although not implicit time, compared with normal subjects.