Vaccination influences the evolution of classical swine fever virus
Vaccination influences the evolution of classical swine fever virus
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DOI：
10.1016/j.meegid.2014.04.008
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发表时间：
2014-07-01
影响因子：
3.2
通讯作者：
He, Cheng-Qiang
中科院分区：
文献类型：
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作者：
Ji, Wei;Niu, Dan-Dan;He, Cheng-Qiang
猪瘟是由猪瘟病毒（classical swine fever virus，CSFV）引起的一种严重的经济损失性疾病。根据系统发育学估计，CSFV由两个进化枝组成。HCLV等减毒活疫苗已被广泛用于保护猪免受CSFV感染，但疫苗接种对CSFV进化的影响尚未研究。我们通过比较疫苗相关和非疫苗相关CSFV群体，对疫苗接种对CSFV进化的影响进行了系统分析。我们发现疫苗接种可能通过重组和点突变影响菌株多样性和免疫逃逸。研究还发现，疫苗接种可能影响猪瘟病毒的种群动态、进化速率和适应性进化。我们的证据表明，疫苗接种也可能通过影响猪中病毒的密码子使用来改变宿主适应性。这些结果提示，有必要避免过度使用猪瘟弱毒疫苗。(C)2014爱思唯尔有限公司版权所有。
Classical swine fever is a serious, economically damaging disease caused by classical swine fever virus (CSFV). The CSFV is composed of two clades, according to phylogenetic estimates. Attenuated live vaccine such as HCLV, has been widely used to protect pigs from CSFV, but the influence of vaccination on the evolution of CSFV has not been studied. We conducted a systemic analysis of the impact of vaccination on the evolution of CSFV by comparing vaccine-related and non-vaccine-related CSFV groups. We found that vaccination may affect strain diversity and immune escape through recombination and point mutation. We also found that vaccination may influence the population dynamics, evolutionary rate and adaptive evolution of classical swine fever virus. Our evidence suggests that the vaccination might also change host adaptation through influencing codon usage of the virus in swine. These findings suggest that it is necessary to avoid excessive use of CSFV attenuated vaccines. (C) 2014 Elsevier B.V. All rights reserved.