The predictive value of semaphorins 3 expression in biopsies for biochemical recurrence of patients with low- and intermediate-risk prostate cancer
The predictive value of semaphorins 3 expression in biopsies for biochemical recurrence of patients with low- and intermediate-risk prostate cancer
复制标题
活检中信号蛋白3表达对低危和中危前列腺癌患者生化复发的预测价值
DOI：
10.4149/neo_2013_087
复制
发表时间：
2013-01-01
期刊：
影响因子：
3
通讯作者：
Gao, X.
中科院分区：
文献类型：
--
作者：
Li, K.;Chen, M. K.;Gao, X.
3类信号素(Sema3A-F，Sema3s)最初被认为在轴突引导和细胞迁移中发挥重要作用。我们以前的研究表明，Sema3也参与了前列腺癌的淋巴转移，并可能根据其亚型的不同而调节前列腺癌的行为，具有促肿瘤或抗肿瘤的作用。然而，目前尚无研究对前列腺癌根治术前活检标本中Sema3s的表达对预测前列腺癌根治术后生化复发的价值进行深入研究。在这项研究中，我们通过免疫组织化学方法评估了198例中低风险局限性前列腺癌组织中Sema3s的表达。所有患者的中位随访期为42个月(6-60个月)。结果显示：Sema3A(OR：0.19，P
The class-3 semaphorins (Sema3A-F, Sema3s) are initially identified to play an important role in axonal guidance and cell migration. Our previous studies showed that Sema3s are also involved in the lymph node metastasis of prostate cancer, and are likely to modulate the behavior of prostate cancer with a pro-tumoral or an anti-tumoral effect, depending on their subtypes. However, no study has critically investigated the value of Sema3s expression in preoperative biopsy samples for the prediction of biochemical recurrence (BCR) after radical prostatectomy. In this study, we evaluated Sema3s expression by immunohistochemistry on 198 prostate biopsies with low- and intermediate-risk localized prostate cancer. The median follow-up was 42 months (range, 6-60) for all patients. Our results showed that Sema3A (OR: 0.19, P