Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice
Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice
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Riparoside B 和 Timosaponin J（来自水茯苓的两种甾体糖苷）基于 URAT1 在高尿酸血症小鼠中抵抗高尿酸血症
DOI：
10.1016/j.phymed.2014.03.009
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发表时间：
2014-09-01
期刊：
影响因子：
7.9
通讯作者：
Zhang, Yan-Wen
中科院分区：
文献类型：
--
作者：
Wu, Xiao-Hui;Zhang, Jun;Zhang, Yan-Wen
摘要川楝科植物牛尾菜（Smilax riparia，SR）的根和根茎被认为是治疗痛风症状的有效药物。然而，尚不清楚S.河岸支持其治疗活性。本研究从知母总皂苷中分离得到两个甾体苷类化合物，分别命名为Riparoside B和Timosaponin J。河岸。然后，我们检查了这两种化合物是否能有效降低氧嗪酸钾诱导的高尿酸血症小鼠模型的血清尿酸水平。结果表明，两种甾体苷类化合物对高尿酸血症小鼠具有明显的促尿酸排泄作用，主要通过降低肾脏mURAT1水平，并在一定程度上抑制XOD活性，从而促进尿酸排泄，减轻高尿酸血症引起的肾功能损害。Riparoside B和知母皂苷J可能在治疗痛风和由高尿酸血症引起的其他医学病症中具有临床效用。(C)2014 Elsevier GmbH. All rights reserved.
The roots and rhizomes of Smilax riparia (SR), called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. However, it is not clear if the active constituents and uricosuric mechanisms of S. riparia support its therapeutic activities. In this study, we isolated two steroidal glycosides named riparoside B and timosaponin J from the total saponins of S. riparia. We then examined if these two compounds were effective in reducing serum uric acid levels in a hyperuricemic mouse model induced by potassium oxonate. We found that the two steroidal glycosides possess potent uricosuric effect in hyperuricemic mice through decreasing renal mURAT1 mainly and inhibiting XOD activity in a certain extent, which contribute to the enhancement of uric acid excretion and attenuate hyperuricemia-induced renal dysfunction. Riparoside B and timosaponin J may have a clinical utility in treating gout and other medical conditions caused by hyperuricemia. (C) 2014 Elsevier GmbH. All rights reserved.