Multiscale modeling of blood flow: from single cells to blood rheology
Multiscale modeling of blood flow: from single cells to blood rheology
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DOI：
10.1007/s10237-013-0497-9
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发表时间：
2014-04-01
影响因子：
3.5
通讯作者：
Gompper, Gerhard
中科院分区：
文献类型：
--
作者：
Fedosov, Dmitry A.;Noguchi, Hiroshi;Gompper, Gerhard
血流的中尺度模拟，其中红细胞被描述为可变形的封闭壳，其膜具有弯曲刚性和拉伸弹性，近年来在预测各种流动中血细胞和其他成分的流动行为方面取得了很大进展。为了对复杂几何形状中的血流和血液相关过程进行数值研究，血浆和溶质的高效模拟技术至关重要。在这篇综述中，我们重点关注单个和多个细胞在剪切和微毛细管流中的行为、血液的剪切稀化行为及其与血细胞结构和相互作用的关系、白细胞和血小板的边缘化以及血液疾病和紊乱的建模。只要有可能，就会将模拟预测与现有的实验结果进行比较，并且通常会获得非常令人满意的一致性。
Mesoscale simulations of blood flow, where the red blood cells are described as deformable closed shells with a membrane characterized by bending rigidity and stretching elasticity, have made much progress in recent years to predict the flow behavior of blood cells and other components in various flows. To numerically investigate blood flow and blood-related processes in complex geometries, a highly efficient simulation technique for the plasma and solutes is essential. In this review, we focus on the behavior of single and several cells in shear and microcapillary flows, the shear-thinning behavior of blood and its relation to the blood cell structure and interactions, margination of white blood cells and platelets, and modeling hematologic diseases and disorders. Comparisons of the simulation predictions with existing experimental results are made whenever possible, and generally very satisfactory agreement is obtained.