The role and function of CLU in cancer biology and therapy
The role and function of CLU in cancer biology and therapy
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DOI：
10.1007/s10238-022-00885-2
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yan Liu
中科院分区：
文献类型：
--
作者：
Yefei Zhang;Xiang Lv;Liming Chen;Yan Liu
Clusterin (CLU) is a highly evolutionary conserved glycoprotein with multiple isoform-specific functions and is widely distributed in different species. Accumulated evidence has shown the prominent role of CLU in regulating several essential physiological processes, including programmed cell death, metastasis, invasion, proliferation and cell growth via regulating diverse signaling pathways to mediate cancer progression in various cancers, such as prostate, breast, lung, liver, colon, bladder and pancreatic cancer. Several studies have revealed the potential benefit of inhibiting CLU in CLU inhibition-based targeted cancer therapies in vitro, in vivo or in human, suggesting CLU is a promising therapeutic target. This review discusses the multiple functions and mechanisms of CLU in regulating tumor progression of various cancers and summarizes the inhibitors of CLU used in CLU inhibition-based targeted cancer therapies.
