Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling
Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling
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DOI：
10.1038/emboj.2011.22
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发表时间：
2011-03-16
期刊：
影响因子：
11.4
通讯作者：
Schafer, William R.
中科院分区：
文献类型：
--
作者：
Ezcurra, Marina;Tanizawa, Yoshinori;Schafer, William R.
许多行为状态受到食物供应和营养状况的调节。在这里，我们报道了秀丽隐杆线虫，外部食物来源的存在增强了多模态ASH神经元对可溶性驱避剂的回避反应。这种增强需要多巴胺信号，并被外源性多巴胺模仿。食物调节依赖于多巴胺能神经元的机械感觉纤毛，表明多巴胺是在对细菌感觉的反应中释放的。多巴胺神经元的激活会在几秒钟内导致感官敏锐度的短暂增加。体内成像实验表明，这种多巴胺依赖性致敏部分是由于ASH神经元中味觉反应的强度和持续时间的模式特异性增加。d1样多巴胺受体dop4在ASH中细胞自主作用，介导对反应强度的影响。因此，多巴胺作为食物存在的直接信号来控制情境依赖的行为状态。生物医学工程学报（2011）30,1110-1122。doi: 10.1038 / emboj.2011.22;2011年2月8日在线发布
Many behavioural states are modulated by food availability and nutritional status. Here, we report that in Caenorhabditis elegans, the presence of an external food source enhances avoidance responses to soluble repellents sensed by the polymodal ASH neurons. This enhancement requires dopamine signalling and is mimicked by exogenous dopamine. Food modulation is dependent on the mechanosensory cilia of the dopaminergic neurons, indicating that dopamine is released in response to sensation of bacteria. Activation of the dopamine neurons leads within seconds to a transient state of increased sensory acuity. In vivo imaging experiments indicate that this dopamine-dependent sensitization results in part from modality-specific increases in the magnitude and duration of gustatory responses in the ASH neurons. The D1-like dopamine receptor DOP-4 acts cell autonomously in ASH to mediate effects on response magnitude. Thus, dopamine functions as a direct signal of the presence of food to control context-dependent behavioural states. The EMBO Journal (2011) 30, 1110-1122. doi:10.1038/emboj.2011.22; Published online 8 February 2011